Sigma non-opioid intracellular receptor 1 · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt Q9R0C9. Use UniProt Q9R0C9 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9R0C9 as the stable identity anchor, then attach disease evidence before program review.
Sigma non-opioid intracellular receptor 1
Review this target as Sigma non-opioid intracellular receptor 1, mapped to UniProt Q9R0C9. Sequence length is 223 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Sigma non-opioid intracellular receptor 1 as ChEMBL target CHEMBL3602, mapped to UniProt Q9R0C9. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Sigma non-opioid intracellular receptor 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | Q9R0C9 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Sigma non-opioid intracellular receptor 1 |
| UniProt Accession | Q9R0C9 |
| Component Type | Protein |
| Sequence Length | 223 aa |
Sigma non-opioid intracellular receptor 1
Review this target as Sigma non-opioid intracellular receptor 1, mapped to UniProt Q9R0C9. Sequence length is 223 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL372700 | 10.96 | Ki | 0.011 | Preclinical |
| CHEMBL59809 | 10.15 | IC50 | 0.07 | Preclinical |
| CHEMBL62002 | 10.15 | IC50 | 0.07 | Preclinical |
| CHEMBL127006 | 10.05 | IC50 | 0.089 | Preclinical |
| CHEMBL473783 | 10.01 | Ki | 0.098 | Preclinical |
| CHEMBL112125 | 9.92 | Ki | 0.12 | Preclinical |
| CHEMBL272899 | 9.92 | Ki | 0.12 | Preclinical |
| CHEMBL61479 | 9.92 | IC50 | 0.12 | Clinical |
| CHEMBL3103201 | 9.9 | Ki | 0.126 | Preclinical |
| CHEMBL178042 | 9.85 | IC50 | 0.14 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 56 | 245 | 7.0 |
| tissue-based format | 43 | 310 | 7.5 |
| cell membrane format | 36 | 286 | 7.3 |
| assay format | 28 | 330 | 7.3 |
| cell-based format | 15 | 6 | 7.0 |
| organism-based format | 2 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 16 | 5 | 4.7 |
| assay format | 1 | 17 | 7.0 |
| cell membrane format | 1 | 3 | 6.1 |