Compound Detail
CHEMBL814
FLUVOXAMINE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL814 |
| Name | FLUVOXAMINE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | CJOFXWAVKWHTFT-XSFVSMFZSA-N |
| Therapeutic | ✓ Yes |
15
Targets
20
Activities
2
Assay Types
10
PK Parameters
20
Publications
3
Known Names
16
Indications
Molecular Properties
318.3
MW (Da)
3.20
ALogP
4
HBA
1
HBD
56.8
PSA (Ų)
0.43
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1994 |
| Availability | Prescription |
| Chirality | Achiral |
Indications
Depressive Disorder Depressive Disorder Depressive Disorder Anxiety Anxiety Disorders Anxiety, Separation Autistic Disorder Dementia Obsessive-Compulsive Disorder Phobia, Social Schizophrenia Severe Acute Respiratory Syndrome Severe Acute Respiratory Syndrome Panic Disorder Post-Acute COVID-19 Syndrome Neoplasms
ATC Classification
N06AB08
fluvoxamine
Level 1: NERVOUS SYSTEM
Level 2: PSYCHOANALEPTICS
Activity Summary
Ki 12 meas. best 8.84
IC50 8 meas. best 8.42
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sodium-dependent dopamine transporter CHEMBL238 | Ki | 8.84 | 8.84 | 1.5 | 1 |
| Sodium-dependent serotonin transporter CHEMBL228 | Ki | 8.51 | 7.425 | 3.1 | 2 |
| Sodium-dependent serotonin transporter CHEMBL228 | IC50 | 8.42 | 8.42 | 3.8 | 1 |
| Sigma non-opioid intracellular receptor 1 CHEMBL287 | Ki | 7.44 | 7.44 | 36.0 | 1 |
| Sigma non-opioid intracellular receptor 1 CHEMBL3602 | Ki | 7.44 | 7.44 | 36.0 | 2 |
| Sodium-dependent serotonin transporter CHEMBL313 | IC50 | 6.27 | 6.27 | 540.0 | 1 |
| Norepinephrine transporter CHEMBL304 | IC50 | 5.72 | 5.72 | 1900.0 | 1 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 CHEMBL240 | IC50 | 5.51 | 5.51 | 3100.0 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1C CHEMBL2366456 | IC50 | 5.31 | 5.31 | 4900.0 | 2 |
| Cytochrome P450 2D6 CHEMBL289 | Ki | 5.1 | 4.935 | 8000.0 | 2 |
| Cytochrome P450 2C9 CHEMBL3397 | Ki | 5.07 | 5.07 | 8500.0 | 1 |
| Sigma intracellular receptor 2 CHEMBL4105864 | Ki | 5.07 | 5.07 | 8439.0 | 1 |
| Unchecked CHEMBL612545 | Ki | 5.07 | 5.07 | 8439.0 | 1 |
| Sodium channel protein type 5 subunit alpha CHEMBL1980 | IC50 | 4.41 | 4.41 | 39400.0 | 1 |
| Sodium-dependent dopamine transporter CHEMBL338 | IC50 | 4.35 | 4.35 | 45000.0 | 1 |
| Cytochrome P450 1A2 CHEMBL1075125 | Ki | 4.24 | 4.24 | 57400.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| F | 79.0 | % | Homo sapiens |
| Fu | 0.022 | - | Homo sapiens |
| Fu | 0.0084 | - | Rattus norvegicus |
| Fu | 0.0074 | - | Sus scrofa |
| Fu | 0.044 | - | Macaca fascicularis |
| Fu | 0.038 | - | Canis lupus familiaris |
| Fu | 0.011 | - | Cavia porcellus |
| Fu | 0.034 | - | Mus musculus |
| Fu | 0.009 | - | Rattus norvegicus |
| Fu | 0.013 | - | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine