Assay Detail
Functional
CHEMBL3436083
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes
1
Total Activities
1
Compounds Tested
1
Activity Types
6
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Heart |
| Cell Type | Ventricular myocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-dependent L-type calcium channel subunit alpha-1C (CHEMBL2366456) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.31 | 5.31 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| CA_SOL_CONC | CA_SOL_CONC | 1.8 | mM | — |
| DETECTION_METHOD | DETECTION_METHOD | - | — | Whole cell PC |
| HOLDING_POTENTIAL | HOLDING_POTENTIAL | - | — | -40 |
| MEAS_VOLT | MEAS_VOLT | - | mV | — |
| T1_PULSE | T1_PULSE | 0.4 | s | — |
| TEMP | TEMP | - | — | room |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL814 | FLUVOXAMINE | 4.0 | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL814 | FLUVOXAMINE | IC50 | = | 4900.0 | nM | 5.31 |