Voltage-dependent L-type calcium channel subunit alpha-1C · SINGLE PROTEIN · Cavia porcellus
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As of 2026-09-13Protein identity stays anchored to UniProt O35505. Use UniProt O35505 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O35505 as the stable identity anchor, then attach disease evidence before program review.
Voltage-dependent L-type calcium channel subunit alpha-1C
Review this target as Voltage-dependent L-type calcium channel subunit alpha-1C, mapped to UniProt O35505. Sequence length is 2169 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Voltage-dependent L-type calcium channel subunit alpha-1C as ChEMBL target CHEMBL2366456, mapped to UniProt O35505. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Voltage-dependent L-type calcium channel subunit alpha-1C |
| Target Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
| UniProt | O35505 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Voltage-dependent L-type calcium channel subunit alpha-1C |
| UniProt Accession | O35505 |
| Component Type | Protein |
| Sequence Length | 2169 aa |
Voltage-dependent L-type calcium channel subunit alpha-1C
Review this target as Voltage-dependent L-type calcium channel subunit alpha-1C, mapped to UniProt O35505. Sequence length is 2169 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2237954 | 10.51 | IC50 | 0.0309 | Preclinical |
| CHEMBL2237953 | 10.36 | IC50 | 0.04365 | Preclinical |
| CHEMBL2237955 | 10.34 | IC50 | 0.04571 | Preclinical |
| CHEMBL2261189 | 10.18 | IC50 | 0.06683 | Preclinical |
| CHEMBL2261183 | 9.89 | IC50 | 0.13 | Preclinical |
| CHEMBL2261188 | 9.88 | IC50 | 0.1321 | Preclinical |
| CHEMBL2261191 | 9.84 | IC50 | 0.1459 | Preclinical |
| CHEMBL2261182 | 9.8 | IC50 | 0.1581 | Preclinical |
| CHEMBL2237950 | 9.74 | IC50 | 0.182 | Preclinical |
| CHEMBL2261187 | 9.67 | IC50 | 0.2118 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 88 | 64 | 5.7 |
| tissue-based format | 15 | 15 | 5.6 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 4 | 92 | 6.4 |
| tissue-based format | 3 | 23 | 9.2 |
| cell-based format | 2 | 0 | — |