Compound Detail
CHEMBL2237955
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Basic Information
| ChEMBL ID | CHEMBL2237955 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SAVFMBZEVLXPHF-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
458.0
MW (Da)
4.21
ALogP
6
HBA
2
HBD
93.3
PSA (Ų)
0.58
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 10.34
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Voltage-dependent L-type calcium channel subunit alpha-1C CHEMBL2366456 | IC50 | 10.34 | 10.34 | 0.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Voltage-dependent L-type calcium channel subunit alpha-1C | IC50 | = | 0.04571 | nM | 10.34 | Inhibition of calcium channel in Cavia porcellus (guinea pig) ileum assessed as ... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1007/s00044-011-9904-x | Mus musculus | 1 |
| - | 10.1007/s00044-009-9171-2 | Voltage-dependent L-type calcium channel subunit alpha-1C | 1 |
Data from ChEMBL 36 via Core Engine