Cytochrome P450 2D6 · SINGLE PROTEIN · Homo sapiens
This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.
Move to another high-traffic target or paste a specific ChEMBL target ID.
Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-13Protein identity stays anchored to UniProt P10635. Use UniProt P10635 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P10635 as the stable identity anchor, then attach disease evidence before program review.
Cytochrome P450 2D6
Review this target as Cytochrome P450 2D6, mapped to UniProt P10635. Sequence length is 497 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cytochrome P450 2D6 as ChEMBL target CHEMBL289, mapped to UniProt P10635. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Cytochrome P450 2D6 is the right protein anchor across sources, using UniProt P10635 as the stable mapping.
Jump to Protein ContextUse this block first when you need the strongest disease program and evidence level in one place.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Cytochrome P450 2D6 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P10635 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cytochrome P450 2D6 |
| UniProt Accession | P10635 |
| Component Type | Protein |
| Sequence Length | 497 aa |
Cytochrome P450 2D6
Review this target as Cytochrome P450 2D6, mapped to UniProt P10635. Sequence length is 497 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL180672 | 10.35 | IC50 | 0.045 | Preclinical |
| CHEMBL382741 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL220360 | 9.23 | IC50 | 0.59 | Clinical |
| CHEMBL157101 | 8.73 | IC50 | 1.86 | Approved |
| CHEMBL1091778 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL1294 | 8.7 | IC50 | 2.0 | Approved |
| CHEMBL538632 | 8.59 | IC50 | 2.6 | Preclinical |
| CHEMBL4857395 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL1204009 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL539650 | 8.4 | IC50 | 4.0 | Preclinical |