Compound Detail
CHEMBL808
ECONAZOLE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL808 |
| Name | ECONAZOLE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | LEZWWPYKPKIXLL-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
74
Targets
137
Activities
3
Assay Types
2
PK Parameters
20
Publications
3
Known Names
1
Indications
Molecular Properties
381.7
MW (Da)
5.80
ALogP
3
HBA
0
HBD
27.1
PSA (Ų)
0.54
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1982 |
| Availability | Prescription |
| Chirality | Racemic |
Indications
Tinea Pedis
ATC Classification
D01AC03
econazole
Level 1: DERMATOLOGICALS
Level 2: ANTIFUNGALS FOR DERMATOLOGICAL USE
G01AF05
econazole
Level 1: GENITO URINARY SYSTEM AND SEX HORMONES
Level 2: GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
Activity Summary
IC50 86 meas. best 7.54
Ki 45 meas. best 6.65
Kd 6 meas. best 7.14
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Thromboxane-A synthase CHEMBL1835 | IC50 | 7.54 | 7.54 | 29.0 | 1 |
| Cytochrome P450 2C19 CHEMBL3622 | IC50 | 7.4 | 7.4 | 40.0 | 1 |
| Trypanosoma cruzi CHEMBL368 | IC50 | 7.4 | 7.4 | 40.0 | 1 |
| Cytochrome P450 3A4 CHEMBL340 | IC50 | 7.3 | 6.68 | 50.0 | 3 |
| Lanosterol 14-alpha demethylase CHEMBL3849 | IC50 | 7.3 | 7.3 | 50.0 | 1 |
| Mycocyclosin synthase CHEMBL1681615 | Kd | 7.14 | 7.14 | 73.0 | 1 |
| Cytochrome P450 2C9 CHEMBL3397 | IC50 | 6.7 | 6.7 | 200.0 | 1 |
| Sterol 14alpha-demethylase CHEMBL5090 | Kd | 6.7 | 6.7 | 200.0 | 1 |
| Sodium-dependent serotonin transporter CHEMBL228 | Ki | 6.65 | 6.65 | 225.0 | 1 |
| Muscarinic acetylcholine receptor M4 CHEMBL1821 | Ki | 6.53 | 6.53 | 296.0 | 1 |
| Cytochrome P450 1A2 CHEMBL3356 | IC50 | 6.52 | 6.52 | 300.0 | 1 |
| 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase CHEMBL4523494 | IC50 | 6.51 | 6.51 | 310.0 | 1 |
| Plasmodium falciparum CHEMBL364 | IC50 | 6.5 | 6.5 | 320.0 | 1 |
| Steroid 17-alpha-hydroxylase/17,20 lyase CHEMBL3522 | Ki | 6.49 | 6.49 | 325.0 | 1 |
| Muscarinic acetylcholine receptor M3 CHEMBL245 | Ki | 6.42 | 6.42 | 379.0 | 1 |
| Cytochrome P450 2D6 CHEMBL289 | IC50 | 6.4 | 6.4 | 400.0 | 1 |
| Transient receptor potential cation channel subfamily M member 8 CHEMBL1075319 | IC50 | 6.38 | 6.38 | 420.0 | 1 |
| Sodium-dependent serotonin transporter CHEMBL228 | IC50 | 6.37 | 6.37 | 423.0 | 1 |
| Delta-type opioid receptor CHEMBL236 | Ki | 6.29 | 6.29 | 508.0 | 1 |
| Muscarinic acetylcholine receptor M1 CHEMBL216 | Ki | 6.2 | 6.2 | 636.0 | 1 |
| Sodium-dependent dopamine transporter CHEMBL238 | Ki | 6.18 | 6.18 | 663.0 | 1 |
| Sodium-dependent dopamine transporter CHEMBL238 | IC50 | 6.08 | 6.08 | 835.0 | 1 |
| Unchecked CHEMBL612545 | Kd | 6.06 | 5.6175 | 880.0 | 4 |
| Indoleamine 2,3-dioxygenase 1 CHEMBL4685 | IC50 | 5.96 | 5.525 | 1100.0 | 2 |
| Muscarinic acetylcholine receptor M2 CHEMBL211 | Ki | 5.94 | 5.94 | 1158.0 | 1 |
| 5-hydroxytryptamine receptor 2A CHEMBL224 | Ki | 5.94 | 5.94 | 1152.0 | 1 |
| Progesterone receptor CHEMBL1909044 | Ki | 5.88 | 5.88 | 1332.0 | 1 |
| Delta-type opioid receptor CHEMBL236 | IC50 | 5.84 | 5.84 | 1442.0 | 1 |
| Histamine H2 receptor CHEMBL1941 | IC50 | 5.8 | 5.8 | 1592.0 | 1 |
| Histamine H2 receptor CHEMBL1941 | Ki | 5.8 | 5.8 | 1565.0 | 1 |
| Alpha-2A adrenergic receptor CHEMBL1867 | Ki | 5.79 | 5.79 | 1622.0 | 1 |
| D(3) dopamine receptor CHEMBL234 | Ki | 5.79 | 5.79 | 1615.0 | 1 |
| Muscarinic acetylcholine receptor M3 CHEMBL245 | IC50 | 5.75 | 5.75 | 1789.0 | 1 |
| Adenosine receptor A3 CHEMBL256 | Ki | 5.74 | 5.74 | 1836.0 | 1 |
| Substance-K receptor CHEMBL2327 | Ki | 5.7 | 5.7 | 2011.0 | 1 |
| Muscarinic acetylcholine receptor M4 CHEMBL1821 | IC50 | 5.67 | 5.67 | 2122.0 | 1 |
| Mu-type opioid receptor CHEMBL233 | Ki | 5.64 | 5.64 | 2311.0 | 1 |
| Sodium-dependent noradrenaline transporter CHEMBL222 | Ki | 5.62 | 5.62 | 2415.0 | 1 |
| Sodium-dependent noradrenaline transporter CHEMBL222 | IC50 | 5.61 | 5.61 | 2435.0 | 1 |
| Muscarinic acetylcholine receptor M1 CHEMBL216 | IC50 | 5.58 | 5.58 | 2642.0 | 1 |
| Alpha-2B adrenergic receptor CHEMBL1942 | Ki | 5.57 | 5.57 | 2677.0 | 1 |
| Unchecked CHEMBL612545 | Ki | 5.53 | 5.336 | 2930.0 | 5 |
| Transient receptor potential cation channel subfamily M member 2 CHEMBL1250402 | IC50 | 5.52 | 5.52 | 3000.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 5.52 | 5.0286 | 3014.0 | 7 |
| Muscarinic acetylcholine receptor M2 CHEMBL211 | IC50 | 5.49 | 5.49 | 3256.0 | 1 |
| D(4) dopamine receptor CHEMBL219 | Ki | 5.49 | 5.49 | 3271.0 | 1 |
| Adenosine receptor A3 CHEMBL256 | IC50 | 5.49 | 5.49 | 3249.0 | 1 |
| Kappa-type opioid receptor CHEMBL237 | Ki | 5.46 | 5.46 | 3446.0 | 1 |
| 5-hydroxytryptamine receptor 2A CHEMBL224 | IC50 | 5.39 | 5.39 | 4034.0 | 1 |
| D(2) dopamine receptor CHEMBL217 | Ki | 5.37 | 5.37 | 4269.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| Cmax | 1.0 | nM | Homo sapiens |
| Tmax | 1.0 | hr | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine