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Target Snapshot

CHEMBL368 Target Snapshot

Trypanosoma cruzi · ORGANISM · Trypanosoma cruzi

82,303Compounds
3,284Assays
120Approved Drugs
17,986.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Trypanosoma cruzi as ChEMBL target CHEMBL368. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Trypanosoma cruzi
ORGANISM · Trypanosoma cruzi
As of 2026-09-13
ChEMBL target ID
CHEMBL368
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Trypanosoma cruzi still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelTrypanosoma cruzi
UniProt AccessionN/A

Trypanosoma cruzi

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Trypanosoma cruzi.

Review nameTrypanosoma cruzi
OrganismTrypanosoma cruzi
Clinical Profile

Clinical Phase Distribution

120
Approved
25
Phase III
31
Phase II
9
Phase I
Assay Mix

Activity Type Distribution

IC5015,770.0
KI31.0
EC502,185.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3259946 10.77 EC50 0.017 Preclinical
CHEMBL110 10.4 EC50 0.04 Approved
CHEMBL2448735 10.0 IC50 0.1 Preclinical
CHEMBL3259944 9.92 EC50 0.12 Preclinical
CHEMBL2448747 9.72 IC50 0.19 Preclinical
CHEMBL2440958 9.7 EC50 0.2 Preclinical
CHEMBL1397 9.6 IC50 0.25 Approved
CHEMBL2448750 9.59 IC50 0.26 Preclinical
CHEMBL157101 9.52 EC50 0.3 Approved
CHEMBL1397 9.52 EC50 0.3 Approved
Distribution

pChEMBL Value Distribution

2386
5.0
1743
5.5
1330
6.0
911
6.5
607
7.0
442
7.5
213
8.0
102
8.5
52
9.0
17
9.5
pChEMBL
Approved Drugs

Approved Drugs

NIFURTIMOX
CHEMBL290960
Approved 2020
BENZNIDAZOLE
CHEMBL110
Approved 2017
MILTEFOSINE
CHEMBL125
Approved 2014
DELAMANID
CHEMBL218650
Approved 2014
POSACONAZOLE
CHEMBL1397
Approved 2005
VORICONAZOLE
CHEMBL638
Approved 2002
AZELASTINE
CHEMBL639
Approved 1996
DOCETAXEL
CHEMBL3545252
Approved 1995
ITRACONAZOLE
CHEMBL64391
Approved 1992
OXICONAZOLE NITRATE
CHEMBL1200836
Approved 1988
TERCONAZOLE
CHEMBL1714574
Approved 1987
AMIODARONE
CHEMBL633
Approved 1985
PENTAMIDINE
CHEMBL55
Approved 1984
TIOCONAZOLE
CHEMBL1200438
Approved 1983
ECONAZOLE
CHEMBL808
Approved 1982
KETOCONAZOLE
CHEMBL157101
Approved 1981
CLOTRIMAZOLE
CHEMBL104
Approved 1975
MICONAZOLE
CHEMBL91
Approved 1974
MICONAZOLE NITRATE
CHEMBL1559
Approved 1974
AMPHOTERICIN B
CHEMBL267345
Approved 1964
FURAZOLIDONE
CHEMBL1103
Approved 1958
Source · ChEMBL 36 via Core Engine