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Evidence Snapshot

Trypanosoma cruzi

CHEMBL368 ORGANISM Trypanosoma cruzi
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T02:29:31Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL368
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Trypanosoma cruzi as ChEMBL target CHEMBL368. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Trypanosoma cruzi
ORGANISM · Trypanosoma cruzi
As of 2026-09-13
ChEMBL target ID
CHEMBL368
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Trypanosoma cruzi matters

As of 2026-09-13

Trypanosoma cruzi is reviewed as Trypanosoma cruzi; the current evidence base includes 120 approved drugs, 82303 compounds, and 3284 assays, with lead potency reaching pChEMBL 10.8.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 120 approved drugs, 82303 compounds, and 3284 assays for this target. The dominant activity type is IC50. CHEMBL3259946 is the current potency anchor at pChEMBL 10.8.

Use CHEMBL3259946 as the tractability anchor when discussing potency (pChEMBL 10.8).

Activity source · ChEMBL 36 via Core Engine
120 approved pChEMBL 10.8
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Trypanosoma cruzi matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

82303
Total Compounds
3284
Total Assays
120
Approved Drugs
IC50: 15770.0, KI: 31.0, EC50: 2185.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL3259946
 10.8 EC50 —
No preferred name
CHEMBL110
 10.4 EC50 Approved
No preferred name
CHEMBL2448735
 10.0 IC50 —
No preferred name
CHEMBL3259944
 9.9 EC50 —
No preferred name
CHEMBL2448747
 9.7 IC50 —

Approved Drugs

Structure Compound First Approval
NIFURTIMOX
CHEMBL290960
 2020
BENZNIDAZOLE
CHEMBL110
 2017
MILTEFOSINE
CHEMBL125
 2014
DELAMANID
CHEMBL218650
 2014
POSACONAZOLE
CHEMBL1397
 2005
VORICONAZOLE
CHEMBL638
 2002
AZELASTINE
CHEMBL639
 1996
DOCETAXEL
CHEMBL3545252
 1995
ITRACONAZOLE
CHEMBL64391
 1992
OXICONAZOLE NITRATE
CHEMBL1200836
 1988
TERCONAZOLE
CHEMBL1714574
 1987
AMIODARONE
CHEMBL633
 1985
PENTAMIDINE
CHEMBL55
 1984
TIOCONAZOLE
CHEMBL1200438
 1983
ECONAZOLE
CHEMBL808
 1982
KETOCONAZOLE
CHEMBL157101
 1981
CLOTRIMAZOLE
CHEMBL104
 1975
MICONAZOLE
CHEMBL91
 1974
MICONAZOLE NITRATE
CHEMBL1559
 1974
AMPHOTERICIN B
CHEMBL267345
 1964
FURAZOLIDONE
CHEMBL1103
 1958
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T02:29:31Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL368