Compound Detail
CHEMBL110
BENZNIDAZOLE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL110 |
| Name | BENZNIDAZOLE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | CULUWZNBISUWAS-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
15
Targets
546
Activities
2
Assay Types
0
PK Parameters
20
Publications
10
Known Names
4
Indications
1
Mechanisms
Molecular Properties
260.2
MW (Da)
1.11
ALogP
5
HBA
1
HBD
90.1
PSA (Ų)
0.64
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2017 |
| Availability | Prescription |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Unknown | - | - | ✓ | ✓ |
Indications
Chagas Disease Chagas Disease Leishmaniasis Trypanosomiasis
ATC Classification
P01CA02
benznidazole
Level 1: ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
Level 2: ANTIPROTOZOALS
Activity Summary
IC50 473 meas. best 8.74
EC50 73 meas. best 10.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Trypanosoma cruzi CHEMBL368 | EC50 | 10.4 | 5.5373 | 0.0 | 64 |
| Trypanosoma cruzi CHEMBL368 | IC50 | 8.74 | 5.1683 | 1.8 | 400 |
| Trypanosoma brucei CHEMBL612849 | EC50 | 7.8 | 6.16 | 16.0 | 2 |
| Vero CHEMBL391 | IC50 | 5.68 | 4.8088 | 2100.0 | 17 |
| Trypanosoma brucei brucei CHEMBL612851 | IC50 | 5.66 | 5.16 | 2200.0 | 4 |
| Trypanosoma brucei CHEMBL612849 | IC50 | 5.49 | 5.49 | 3240.0 | 1 |
| NON-PROTEIN TARGET CHEMBL3879801 | EC50 | 5.4 | 5.4 | 3960.0 | 1 |
| Plasmodium berghei CHEMBL612653 | IC50 | 5.39 | 5.39 | 4070.0 | 1 |
| Entamoeba histolytica CHEMBL612853 | IC50 | 5.37 | 5.37 | 4270.0 | 2 |
| Unchecked CHEMBL612545 | IC50 | 5.07 | 5.07 | 8500.0 | 1 |
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 4.8 | 4.8 | 16000.0 | 1 |
| Trichomonas vaginalis CHEMBL612884 | IC50 | 4.73 | 4.73 | 18620.0 | 4 |
| Giardia intestinalis CHEMBL612652 | IC50 | 4.65 | 4.65 | 22580.0 | 4 |
| HepG2 CHEMBL395 | IC50 | 4.55 | 4.55 | 28100.0 | 1 |
| H9c2 CHEMBL614576 | IC50 | 4.5 | 4.5 | 31622.8 | 1 |
| MRC5 CHEMBL614181 | IC50 | 4.33 | 4.33 | 47200.0 | 1 |
| Cytochrome P450 2D6 CHEMBL289 | IC50 | 4.11 | 4.11 | 77800.0 | 1 |
| Cytochrome P450 3A4 CHEMBL340 | IC50 | 4.01 | 4.01 | 98200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine