Assay Detail
Functional
CHEMBL4345856
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma cruzi CL Brener amastigotes infected in African green monkey Vero cells assessed as reduction in parasite growth incubated for 120 hrs at 24 hrs post-infection and measured on day 6 post-infection by hemocytometer based light microscopy
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New 8-Nitroquinolinone Derivative Displaying Submicromolar in Vitro Activities against Both Trypanosoma brucei and cruzi.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.04 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4565434 | — | — | 1 | 6.30 |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | 6.30 |
| CHEMBL1631694 | FEXINIDAZOLE | 4.0 | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4565434 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL110 | BENZNIDAZOLE | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1631694 | FEXINIDAZOLE | EC50 | = | 3000.0 | nM | 5.52 |