Compound Detail
CHEMBL1631694
FEXINIDAZOLE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1631694 |
| Name | FEXINIDAZOLE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | MIWWSGDADVMLTG-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
6
Targets
35
Activities
2
Assay Types
5
PK Parameters
20
Publications
4
Known Names
7
Indications
1
Mechanisms
Molecular Properties
279.3
MW (Da)
2.63
ALogP
6
HBA
0
HBD
70.2
PSA (Ų)
0.48
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2021 |
| Availability | Prescription |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Cytotoxic | - | - | ✓ | ✓ |
Indications
Leishmaniasis Trypanosomiasis Trypanosomiasis, African Chagas Disease Chagas Disease Infections Leishmaniasis, Visceral
ATC Classification
P01CA03
fexinidazole
Level 1: ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
Level 2: ANTIPROTOZOALS
Activity Summary
EC50 18 meas. best 6.4
IC50 17 meas. best 6.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Trypanosoma brucei brucei CHEMBL612851 | EC50 | 6.4 | 6.28 | 400.0 | 3 |
| Trypanosoma brucei brucei CHEMBL612851 | IC50 | 6.4 | 6.28 | 400.0 | 3 |
| Trypanosoma brucei rhodesiense CHEMBL612348 | IC50 | 6.16 | 5.8225 | 700.0 | 4 |
| Trypanosoma brucei rhodesiense CHEMBL612348 | EC50 | 6.12 | 6.12 | 760.0 | 1 |
| Trypanosoma brucei CHEMBL612849 | EC50 | 6.0 | 5.1857 | 1000.0 | 7 |
| Trypanosoma brucei CHEMBL612849 | IC50 | 6.0 | 6.0 | 1000.0 | 1 |
| Leishmania donovani CHEMBL367 | EC50 | 5.92 | 5.7967 | 1200.0 | 3 |
| Leishmania donovani CHEMBL367 | IC50 | 5.92 | 5.66 | 1200.0 | 4 |
| Trypanosoma cruzi CHEMBL368 | EC50 | 5.52 | 5.52 | 3000.0 | 2 |
| Leishmania infantum CHEMBL612848 | EC50 | 5.47 | 5.47 | 3400.0 | 2 |
| Leishmania infantum CHEMBL612848 | IC50 | 5.47 | 5.47 | 3400.0 | 3 |
| Trypanosoma cruzi CHEMBL368 | IC50 | 5.05 | 5.05 | 8900.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| Cmax | 3440.5 | nM | Mus musculus |
| Fu | 0.147 | - | Mus musculus |
| T1/2 | 0.8 | hr | Mus musculus |
| T1/2 | 0.8 | hr | Mus musculus |
| Tmax | 0.25 | hr | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine