Assay Detail
Functional
CHEMBL4773767
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against Leishmania donovani MHOM/IN/00/DEVI promastigotes assessed as inhibition of parasitic metabolic activity measured after 72 hrs by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antikinetoplastid SAR study in 3-nitroimidazopyridine series: Identification of a novel non-genotoxic and potent anti-T. b. brucei hit-compound with improved pharmacokinetic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 5.72 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 7.16 |
| CHEMBL4788930 | — | — | 1 | 6.30 |
| CHEMBL4798187 | — | — | 1 | 6.16 |
| CHEMBL4792432 | — | — | 1 | 6.10 |
| CHEMBL4785404 | — | — | 1 | 6.05 |
| CHEMBL1631694 | FEXINIDAZOLE | 4.0 | 1 | 5.92 |
| CHEMBL4789978 | — | — | 1 | 5.92 |
| CHEMBL4797467 | — | — | 1 | 5.72 |
| CHEMBL4777198 | — | — | 1 | 5.72 |
| CHEMBL4793961 | — | — | 1 | 5.60 |
| CHEMBL4783344 | — | — | 1 | 5.58 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 5.51 |
| CHEMBL4783634 | — | — | 1 | 5.40 |
| CHEMBL4784988 | — | — | 1 | 5.25 |
| CHEMBL4776584 | — | — | 1 | 5.24 |
| CHEMBL4780635 | — | — | 1 | 5.21 |
| CHEMBL4781188 | — | — | 1 | 5.13 |
| CHEMBL4783616 | — | — | 1 | 5.03 |
| CHEMBL4780577 | — | — | 1 | - |
| CHEMBL4791191 | — | — | 1 | - |
| CHEMBL4799356 | — | — | 1 | - |
| CHEMBL4777308 | — | — | 1 | - |
| CHEMBL4791331 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4788930 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4798187 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4792432 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4785404 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1631694 | FEXINIDAZOLE | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4789978 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4797467 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4777198 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4793961 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4783344 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL125 | MILTEFOSINE | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4783634 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4784988 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4776584 | — | EC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4780635 | — | EC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4781188 | — | EC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4783616 | — | EC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL4780577 | — | EC50 | > | 12500.0 | nM | - |
| CHEMBL4791191 | — | EC50 | > | 12500.0 | nM | - |
| CHEMBL4799356 | — | EC50 | > | 12500.0 | nM | - |
| CHEMBL4777308 | — | EC50 | > | 12500.0 | nM | - |
| CHEMBL4791331 | — | EC50 | > | 12500.0 | nM | - |