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Compound Detail

CHEMBL4783616

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O=[N+]([O-])c1cnc2c(Br)cc(Cl)cn12

Basic Information

ChEMBL ID CHEMBL4783616
Phase Preclinical
Structure Type MOL
InChI Key UUNOBPZRFNJWHM-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

276.5
MW (Da)
2.66
ALogP
4
HBA
0
HBD
60.4
PSA (Ų)
0.59
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C7H3BrClN3O2
MW 276.48
Aromatic Rings 2
Heavy Atoms 14
NP-Likeness -1.99

Activity Summary

EC50 3 meas. best 6.4

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Trypanosoma brucei brucei
CHEMBL612851
EC50 6.4 6.4 400.0 1
Leishmania donovani
CHEMBL367
EC50 5.03 5.03 9300.0 1
Leishmania infantum
CHEMBL612848
EC50 4.8 4.8 15900.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
32795774 10.1016/j.ejmech.2020.112668 Unchecked 3
32795774 10.1016/j.ejmech.2020.112668 HepG2 1
32795774 10.1016/j.ejmech.2020.112668 Leishmania donovani 1
32795774 10.1016/j.ejmech.2020.112668 Leishmania infantum 1
32795774 10.1016/j.ejmech.2020.112668 Trypanosoma brucei brucei 1

Data from ChEMBL 36 via Core Engine