Assay Detail
Functional
CHEMBL4773771
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Antitrypanosomal activity against bloodstream form Trypanosoma brucei brucei AnTat 1.9 trypomastigotes assessed as reduction in parasite viability incubated for 69 hrs by Alamar Blue dye based assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antikinetoplastid SAR study in 3-nitroimidazopyridine series: Identification of a novel non-genotoxic and potent anti-T. b. brucei hit-compound with improved pharmacokinetic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 6.36 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4776584 | — | — | 1 | 7.77 |
| CHEMBL4794493 | — | — | 1 | 7.70 |
| CHEMBL4792432 | — | — | 1 | 7.60 |
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 7.52 |
| CHEMBL4789978 | — | — | 1 | 7.17 |
| CHEMBL4793961 | — | — | 1 | 7.07 |
| CHEMBL4797467 | — | — | 1 | 6.77 |
| CHEMBL4798187 | — | — | 1 | 6.52 |
| CHEMBL4783616 | — | — | 1 | 6.40 |
| CHEMBL4785404 | — | — | 1 | 6.30 |
| CHEMBL1631694 | FEXINIDAZOLE | 4.0 | 1 | 6.22 |
| CHEMBL4788930 | — | — | 1 | 5.92 |
| CHEMBL4784988 | — | — | 1 | 5.92 |
| CHEMBL4777198 | — | — | 1 | 5.82 |
| CHEMBL4783344 | — | — | 1 | 5.75 |
| CHEMBL4792857 | — | — | 1 | 5.66 |
| CHEMBL290960 | NIFURTIMOX | 4.0 | 1 | 5.58 |
| CHEMBL4780635 | — | — | 1 | 5.40 |
| CHEMBL4791331 | — | — | 1 | 5.14 |
| CHEMBL830 | EFLORNITHINE | 4.0 | 1 | 4.88 |
| CHEMBL4781188 | — | — | 1 | - |
| CHEMBL4783634 | — | — | 1 | - |
| CHEMBL4791191 | — | — | 1 | - |
| CHEMBL4799356 | — | — | 1 | - |
| CHEMBL4777308 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4776584 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4794493 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4792432 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL265502 | SURAMIN | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4789978 | — | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL4793961 | — | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL4797467 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4798187 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4783616 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4785404 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1631694 | FEXINIDAZOLE | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4788930 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4784988 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4777198 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4783344 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4792857 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL290960 | NIFURTIMOX | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4780635 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4791331 | — | EC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL830 | EFLORNITHINE | EC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL4781188 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4783634 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4791191 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4799356 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4777308 | — | EC50 | > | 50000.0 | nM | - |