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Compound Detail

CHEMBL4798187

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O=[N+]([O-])c1c(CS(=O)(=O)c2ccccc2)nc2c([Se]c3ccc(Cl)cc3)cc(Cl)cn12

Basic Information

ChEMBL ID CHEMBL4798187
Phase Preclinical
Structure Type MOL
InChI Key HQGAASKYDCNWNG-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

541.3
MW (Da)

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H13Cl2N3O4SSe
MW 541.27

Activity Summary

EC50 3 meas. best 6.52

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Trypanosoma brucei brucei
CHEMBL612851
EC50 6.52 6.52 300.0 1
Leishmania donovani
CHEMBL367
EC50 6.16 6.16 700.0 1
Leishmania infantum
CHEMBL612848
EC50 6.05 6.05 900.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
32795774 10.1016/j.ejmech.2020.112668 Unchecked 3
32795774 10.1016/j.ejmech.2020.112668 HepG2 1
32795774 10.1016/j.ejmech.2020.112668 Leishmania donovani 1
32795774 10.1016/j.ejmech.2020.112668 Leishmania infantum 1
32795774 10.1016/j.ejmech.2020.112668 Trypanosoma brucei brucei 1
32795774 10.1016/j.ejmech.2020.112668 No relevant target 1

Data from ChEMBL 36 via Core Engine