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Target Snapshot

CHEMBL612851 Target Snapshot

Trypanosoma brucei brucei · ORGANISM · Trypanosoma brucei brucei

9,298Compounds
1,042Assays
37Approved Drugs
10,709.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Trypanosoma brucei brucei as ChEMBL target CHEMBL612851. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Trypanosoma brucei brucei
ORGANISM · Trypanosoma brucei brucei
As of 2026-09-13
ChEMBL target ID
CHEMBL612851
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Trypanosoma brucei brucei still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelTrypanosoma brucei brucei
UniProt AccessionN/A

Trypanosoma brucei brucei

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Trypanosoma brucei brucei.

Review nameTrypanosoma brucei brucei
OrganismTrypanosoma brucei brucei
Clinical Profile

Clinical Phase Distribution

37
Approved
11
Phase III
25
Phase II
8
Phase I
Assay Mix

Activity Type Distribution

IC507,611.0
EC503,098.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL55 9.96 EC50 0.11 Approved
CHEMBL4249714 9.6 EC50 0.25 Preclinical
CHEMBL477683 9.35 EC50 0.45 Preclinical
CHEMBL3358120 9.22 EC50 0.6 Preclinical
CHEMBL56640 9.15 EC50 0.7 Preclinical
CHEMBL4098620 9.1 EC50 0.8 Preclinical
CHEMBL4245918 9.1 EC50 0.8 Preclinical
CHEMBL935 9.07 IC50 0.86 Preclinical
CHEMBL227559 9.05 EC50 0.9 Preclinical
CHEMBL258727 9.05 EC50 0.9 Preclinical
Distribution

pChEMBL Value Distribution

1551
5.0
1220
5.5
1216
6.0
840
6.5
464
7.0
258
7.5
149
8.0
101
8.5
21
9.0
2
9.5
pChEMBL
Approved Drugs

Approved Drugs

FEXINIDAZOLE
CHEMBL1631694
Approved 2021
NIFURTIMOX
CHEMBL290960
Approved 2020
METHYLENE BLUE CATION
CHEMBL191083
Approved 2011
ROMIDEPSIN
CHEMBL343448
Approved 2009
PACLITAXEL
CHEMBL428647
Approved 1992
MITOXANTRONE HYDROCHLORIDE
CHEMBL1417019
Approved 1987
PENTAMIDINE
CHEMBL55
Approved 1984
PENTAMIDINE ISETHIONATE
CHEMBL361506
Approved 1984
CYCLOSPORINE
CHEMBL160
Approved 1983
MITOMYCIN
CHEMBL105
Approved 1981
CHLORHEXIDINE
CHEMBL790
Approved 1976
VINBLASTINE
CHEMBL159
Approved 1965
VINCRISTINE
CHEMBL90555
Approved 1963
METHOTREXATE
CHEMBL34259
Approved 1953
Assay Landscape

Assay Landscape

1,042
Total Assays
5,458
Tested Compounds
3
Assay Types
Functional — 1,038 assays, 5,458 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 940 5,007 5.9
assay format 93 446 6.0
cell-based format 5 5 6.6
ADME — 3 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 3 0
Unassigned — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine