Assay Detail
Functional
CHEMBL4773769
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Antileishmanial activity against Leishmania infantum MHOM/MA/67/ITMAP-263 axenic amastigotes assessed as inhibition of parasitic metabolic activity incubated for 48 hrs by steady Glow reagent based luminescence assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania infantum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antikinetoplastid SAR study in 3-nitroimidazopyridine series: Identification of a novel non-genotoxic and potent anti-T. b. brucei hit-compound with improved pharmacokinetic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 5.33 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 7.22 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 6.10 |
| CHEMBL4788930 | — | — | 1 | 6.10 |
| CHEMBL4798187 | — | — | 1 | 6.05 |
| CHEMBL4777198 | — | — | 1 | 5.80 |
| CHEMBL1631694 | FEXINIDAZOLE | 4.0 | 1 | 5.47 |
| CHEMBL4783344 | — | — | 1 | 5.30 |
| CHEMBL4783634 | — | — | 1 | 5.10 |
| CHEMBL4789978 | — | — | 1 | 4.99 |
| CHEMBL4783616 | — | — | 1 | 4.80 |
| CHEMBL4791191 | — | — | 1 | 4.75 |
| CHEMBL4777308 | — | — | 1 | 4.49 |
| CHEMBL4799356 | — | — | 1 | 4.33 |
| CHEMBL4792432 | — | — | 1 | 4.11 |
| CHEMBL4791331 | — | — | 1 | - |
| CHEMBL4784988 | — | — | 1 | - |
| CHEMBL4785404 | — | — | 1 | - |
| CHEMBL4776584 | — | — | 1 | - |
| CHEMBL4780635 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL125 | MILTEFOSINE | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4788930 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4798187 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4777198 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1631694 | FEXINIDAZOLE | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4783344 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4783634 | — | EC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL4789978 | — | EC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL4783616 | — | EC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL4791191 | — | EC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL4777308 | — | EC50 | = | 32100.0 | nM | 4.49 |
| CHEMBL4799356 | — | EC50 | = | 46300.0 | nM | 4.33 |
| CHEMBL4792432 | — | EC50 | = | 77800.0 | nM | 4.11 |
| CHEMBL4791331 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4784988 | — | EC50 | > | 3100.0 | nM | - |
| CHEMBL4785404 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4776584 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL4780635 | — | EC50 | > | 3100.0 | nM | - |