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Assay Detail

CHEMBL1670965

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antimicrobial activity against Trypanosoma brucei rhodesiense after 48 hrs by proliferation assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma brucei rhodesiense
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma brucei rhodesiense (CHEMBL612348)
Type ORGANISM
Organism Trypanosoma brucei rhodesiense

Publication

Compounds containing 2-substituted imidazole ring for treatment against human African trypanosomiasis.
Samant BS, Sukhthankar MG.
Bioorg Med Chem Lett (2011) 21 : 1015 -1018
PubMed 21211967 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.83 6.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1668874 1 6.60
CHEMBL1668876 1 6.43
CHEMBL1668875 1 6.26
CHEMBL1668881 1 6.17
CHEMBL1631694 FEXINIDAZOLE 4.0 1 6.16
CHEMBL1668880 1 4.60
CHEMBL1667874 1 4.57
CHEMBL1668888 1 -
CHEMBL1668887 1 -
CHEMBL1668886 1 -
CHEMBL1668885 1 -
CHEMBL1668884 1 -
CHEMBL1668883 1 -
CHEMBL1668882 1 -
CHEMBL1668877 1 -
CHEMBL1668878 1 -
CHEMBL1668879 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1668874 IC50 = 250.0 nM 6.60
CHEMBL1668876 IC50 = 370.0 nM 6.43
CHEMBL1668875 IC50 = 550.0 nM 6.26
CHEMBL1668881 IC50 = 670.0 nM 6.17
CHEMBL1631694 FEXINIDAZOLE IC50 = 700.0 nM 6.16
CHEMBL1668880 IC50 = 25000.0 nM 4.60
CHEMBL1667874 IC50 = 27000.0 nM 4.57
CHEMBL1668888 IC50 > 30000.0 nM -
CHEMBL1668887 IC50 > 30000.0 nM -
CHEMBL1668886 IC50 > 30000.0 nM -
CHEMBL1668885 IC50 > 30000.0 nM -
CHEMBL1668884 IC50 > 30000.0 nM -
CHEMBL1668883 IC50 > 30000.0 nM -
CHEMBL1668882 IC50 > 30000.0 nM -
CHEMBL1668877 IC50 > 30000.0 nM -
CHEMBL1668878 IC50 > 30000.0 nM -
CHEMBL1668879 IC50 > 30000.0 nM -