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Target Snapshot

CHEMBL612348 Target Snapshot

Trypanosoma brucei rhodesiense · ORGANISM · Trypanosoma brucei rhodesiense

Back to Search Search this target Browse approvals Evidence Card
5,446Compounds
784Assays
62Approved Drugs
5,539.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Trypanosoma brucei rhodesiense as ChEMBL target CHEMBL612348. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Trypanosoma brucei rhodesiense
ORGANISM · Trypanosoma brucei rhodesiense
As of 2026-09-14
ChEMBL target ID
CHEMBL612348
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Trypanosoma brucei rhodesiense still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameTrypanosoma brucei rhodesiense
Target TypeORGANISM
OrganismTrypanosoma brucei rhodesiense
ChEMBL ↗ NCBI Taxonomy ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelTrypanosoma brucei rhodesiense
UniProt AccessionN/A

Trypanosoma brucei rhodesiense

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Trypanosoma brucei rhodesiense.

Review nameTrypanosoma brucei rhodesiense
OrganismTrypanosoma brucei rhodesiense
Clinical Profile

Clinical Phase Distribution

62
Approved
19
Phase III
13
Phase II
3
Phase I
Assay Mix

Activity Type Distribution

IC505,168.0
EC50371.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL467047 10.0 IC50 0.1 Preclinical
CHEMBL4085387 9.7 IC50 0.2 Preclinical
CHEMBL4066422 9.3 IC50 0.5 Preclinical
CHEMBL2023963 9.28 EC50 0.52 Preclinical
CHEMBL4072767 9.22 IC50 0.6 Preclinical
CHEMBL4099235 9.22 IC50 0.6 Preclinical
CHEMBL4099651 9.22 IC50 0.6 Preclinical
CHEMBL55 9.22 EC50 0.6 Approved
CHEMBL1081709 9.0 IC50 1.0 Preclinical
CHEMBL258320 9.0 IC50 1.0 Preclinical
Distribution

pChEMBL Value Distribution

621
5.0
651
5.5
555
6.0
408
6.5
273
7.0
222
7.5
285
8.0
77
8.5
18
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

FEXINIDAZOLE
CHEMBL1631694
Approved 2021
Properties Compare Identifier
RIFAMYCIN
CHEMBL437765
Approved 2018
Properties Compare Identifier
IBANDRONIC ACID
CHEMBL997
Approved 1996
Properties Compare Identifier
SERTRALINE
CHEMBL809
Approved 1991
Properties Compare Identifier
PENTAMIDINE
CHEMBL55
Approved 1984
Properties Compare Identifier
PENTAMIDINE ISETHIONATE
CHEMBL361506
Approved 1984
Properties Compare Identifier
TIOCONAZOLE
CHEMBL1200438
Approved 1983
Properties Compare Identifier
NITROFURANTOIN
CHEMBL572
Approved 1953
Properties Compare Identifier
Assay Landscape

Assay Landscape

784
Total Assays
4,036
Tested Compounds
2
Assay Types
Functional — 776 assays, 4,036 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 758 3,875 5.9
assay format 18 161 6.7
ADME — 8 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 8 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine