Assay Detail
Functional
CHEMBL2050000
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 by Alamar blue growth inhibition assay
55
Total Activities
55
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Discovery of nitroheterocycles active against African trypanosomes. In vitro screening and preliminary SAR studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 55 | 4.71 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 8.30 |
| CHEMBL1631694 | FEXINIDAZOLE | 4.0 | 1 | 5.77 |
| CHEMBL2046928 | — | — | 1 | 5.28 |
| CHEMBL2046855 | — | — | 1 | 5.25 |
| CHEMBL2013154 | — | — | 1 | 5.15 |
| CHEMBL2046854 | — | — | 1 | 5.13 |
| CHEMBL2013146 | — | — | 1 | 5.09 |
| CHEMBL2046927 | — | — | 1 | 4.97 |
| CHEMBL2046856 | — | — | 1 | 4.85 |
| CHEMBL2046935 | — | — | 1 | 4.84 |
| CHEMBL2046853 | — | — | 1 | 4.77 |
| CHEMBL2013149 | — | — | 1 | 4.70 |
| CHEMBL2046934 | — | — | 1 | 4.67 |
| CHEMBL2046848 | — | — | 1 | 4.64 |
| CHEMBL2046852 | — | — | 1 | 4.42 |
| CHEMBL2046843 | — | — | 1 | 4.40 |
| CHEMBL2046932 | — | — | 1 | 4.31 |
| CHEMBL1971706 | — | — | 1 | 4.30 |
| CHEMBL2046849 | — | — | 1 | 4.26 |
| CHEMBL2046851 | — | — | 1 | 4.25 |
| CHEMBL2046942 | — | — | 1 | 4.24 |
| CHEMBL2046940 | — | — | 1 | 4.21 |
| CHEMBL2046936 | — | — | 1 | 4.20 |
| CHEMBL1997945 | — | — | 1 | 4.17 |
| CHEMBL2003700 | — | — | 1 | 4.13 |
| CHEMBL2046941 | — | — | 1 | 4.09 |
| CHEMBL2046850 | — | — | 1 | 4.08 |
| CHEMBL1969885 | — | — | 1 | 4.06 |
| CHEMBL2013151 | — | — | 1 | 4.01 |
| CHEMBL2046943 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1631694 | FEXINIDAZOLE | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL2046928 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL2046855 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL2013154 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL2046854 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL2013146 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL2046927 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL2046856 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL2046935 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL2046853 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL2013149 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL2046934 | — | IC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL2046848 | — | IC50 | = | 23100.0 | nM | 4.64 |
| CHEMBL2046852 | — | IC50 | = | 37600.0 | nM | 4.42 |
| CHEMBL2046843 | — | IC50 | = | 40200.0 | nM | 4.40 |
| CHEMBL2046932 | — | IC50 | = | 48900.0 | nM | 4.31 |
| CHEMBL1971706 | — | IC50 | = | 49500.0 | nM | 4.30 |
| CHEMBL2046849 | — | IC50 | = | 55500.0 | nM | 4.26 |
| CHEMBL2046851 | — | IC50 | = | 55900.0 | nM | 4.25 |
| CHEMBL2046942 | — | IC50 | = | 57600.0 | nM | 4.24 |
| CHEMBL2046940 | — | IC50 | = | 61100.0 | nM | 4.21 |
| CHEMBL2046936 | — | IC50 | = | 63400.0 | nM | 4.20 |
| CHEMBL1997945 | — | IC50 | = | 66800.0 | nM | 4.17 |
| CHEMBL2003700 | — | IC50 | = | 73400.0 | nM | 4.13 |
| CHEMBL2046941 | — | IC50 | = | 80500.0 | nM | 4.09 |
| CHEMBL2046850 | — | IC50 | = | 82200.0 | nM | 4.08 |
| CHEMBL1969885 | — | IC50 | = | 86400.0 | nM | 4.06 |
| CHEMBL2013151 | — | IC50 | = | 97300.0 | nM | 4.01 |
| CHEMBL2046924 | — | IC50 | = | 192100.0 | nM | - |
| CHEMBL2046923 | — | IC50 | > | 494000.0 | nM | - |
| CHEMBL2046931 | — | IC50 | = | 212900.0 | nM | - |
| CHEMBL2013144 | — | IC50 | = | 162600.0 | nM | - |
| CHEMBL1984585 | — | IC50 | = | 252000.0 | nM | - |
| CHEMBL2013145 | — | IC50 | = | 162700.0 | nM | - |
| CHEMBL2046933 | — | IC50 | = | 138100.0 | nM | - |
| CHEMBL2046937 | — | IC50 | = | 191100.0 | nM | - |
| CHEMBL1881695 | N',N'-DIBENZYLBENZOHYDRAZIDE | IC50 | > | 316000.0 | nM | - |
| CHEMBL2046938 | — | IC50 | = | 153500.0 | nM | - |
| CHEMBL2046939 | — | IC50 | = | 121500.0 | nM | - |
| CHEMBL2046847 | — | IC50 | = | 211800.0 | nM | - |
| CHEMBL2046846 | — | IC50 | > | 410000.0 | nM | - |
| CHEMBL2046845 | — | IC50 | = | 320300.0 | nM | - |
| CHEMBL2013152 | — | IC50 | = | 179800.0 | nM | - |
| CHEMBL2046844 | — | IC50 | > | 365000.0 | nM | - |
| CHEMBL2013155 | — | IC50 | = | 119200.0 | nM | - |
| CHEMBL2046842 | — | IC50 | = | 166200.0 | nM | - |
| CHEMBL2046841 | — | IC50 | > | 419000.0 | nM | - |
| CHEMBL2046929 | — | IC50 | = | 198100.0 | nM | - |
| CHEMBL2046943 | — | IC50 | = | 100600.0 | nM | - |