Assay Detail
Functional
CHEMBL4274064
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Antitrypanosomal activity against trypomastigote stage of Trypanosoma brucei brucei AnTat 1.9 assessed as decrease in parasite viability after 69 hrs by Alamar blue assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
8-Aryl-6-chloro-3-nitro-2-(phenylsulfonylmethyl)imidazo[1,2-a]pyridines as potent antitrypanosomatid molecules bioactivated by type 1 nitroreductases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.58 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 7.52 |
| CHEMBL4288624 | — | — | 1 | 7.40 |
| CHEMBL4280716 | — | — | 1 | 7.16 |
| CHEMBL4290803 | — | — | 1 | 7.10 |
| CHEMBL4282515 | — | — | 1 | 7.05 |
| CHEMBL4290387 | — | — | 1 | 6.82 |
| CHEMBL4280330 | — | — | 1 | 6.80 |
| CHEMBL4278089 | — | — | 1 | 6.70 |
| CHEMBL4285279 | — | — | 1 | 6.64 |
| CHEMBL4277324 | — | — | 1 | 6.60 |
| CHEMBL4290964 | — | — | 1 | 6.51 |
| CHEMBL4280160 | — | — | 1 | 6.39 |
| CHEMBL4294199 | — | — | 1 | 6.37 |
| CHEMBL1631694 | FEXINIDAZOLE | 4.0 | 1 | 6.22 |
| CHEMBL4276734 | — | — | 1 | 6.21 |
| CHEMBL2441910 | — | — | 1 | 5.54 |
| CHEMBL222838 | EFLORNITHINE, (S)- | 2.0 | 1 | 4.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL265502 | SURAMIN | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4288624 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4280716 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4290803 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4282515 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4290387 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4280330 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4278089 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4285279 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4277324 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4290964 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4280160 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4294199 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL1631694 | FEXINIDAZOLE | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4276734 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL2441910 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL222838 | EFLORNITHINE, (S)- | IC50 | = | 13300.0 | nM | 4.88 |