Assay Detail
Functional
CHEMBL4385407
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against promastigote stage of Leishmania donovani MHOM/IN/00/DEVI after 72 hrs by MTT assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Nongenotoxic 3-Nitroimidazo[1,2-<i>a</i>]pyridines Are NTR1 Substrates That Display Potent <i>in Vitro</i> Antileishmanial Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.79 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 7.16 |
| CHEMBL4462553 | — | — | 1 | 6.16 |
| CHEMBL4534157 | — | — | 1 | 6.00 |
| CHEMBL4450630 | — | — | 1 | 6.00 |
| CHEMBL1631694 | FEXINIDAZOLE | 4.0 | 1 | 5.92 |
| CHEMBL4446037 | — | — | 1 | 5.92 |
| CHEMBL4456648 | — | — | 1 | 5.92 |
| CHEMBL4476522 | — | — | 1 | 5.89 |
| CHEMBL4473587 | — | — | 1 | 5.89 |
| CHEMBL4585177 | — | — | 1 | 5.89 |
| CHEMBL4517971 | — | — | 1 | 5.85 |
| CHEMBL4434868 | — | — | 1 | 5.85 |
| CHEMBL4475668 | — | — | 1 | 5.85 |
| CHEMBL4540699 | — | — | 1 | 5.82 |
| CHEMBL4543711 | — | — | 1 | 5.82 |
| CHEMBL4586234 | — | — | 1 | 5.80 |
| CHEMBL4460412 | — | — | 1 | 5.77 |
| CHEMBL4472258 | — | — | 1 | 5.77 |
| CHEMBL4577307 | — | — | 1 | 5.77 |
| CHEMBL4585909 | — | — | 1 | 5.70 |
| CHEMBL4538880 | — | — | 1 | 5.68 |
| CHEMBL4578653 | — | — | 1 | 5.64 |
| CHEMBL4578871 | — | — | 1 | 5.64 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 5.51 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 5.22 |
| CHEMBL4543568 | — | — | 1 | 4.18 |
| CHEMBL4468190 | — | — | 1 | - |
| CHEMBL4455929 | — | — | 1 | - |
| CHEMBL4574704 | — | — | 1 | - |
| CHEMBL4546311 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4462553 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4534157 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4450630 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1631694 | FEXINIDAZOLE | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4446037 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4456648 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4476522 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4473587 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4585177 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4517971 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4434868 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4475668 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4540699 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4543711 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4586234 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4460412 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4472258 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4577307 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4585909 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4538880 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4578653 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4578871 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4543568 | — | IC50 | = | 65600.0 | nM | 4.18 |
| CHEMBL4468190 | — | IC50 | - | — | - | |
| CHEMBL4455929 | — | IC50 | - | — | - | |
| CHEMBL4574704 | — | IC50 | - | — | - | |
| CHEMBL4546311 | — | IC50 | - | — | - |