Assay Detail
Functional
CHEMBL4771960
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Antileishmanial activity against Trypanosoma brucei brucei AnTat 1.9 measured after 74 hrs by Alamar blue assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
8-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruzi.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 6.45 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 7.52 |
| CHEMBL4779309 | — | — | 1 | 7.40 |
| CHEMBL4787217 | — | — | 1 | 7.16 |
| CHEMBL4780415 | — | — | 1 | 7.00 |
| CHEMBL4791697 | — | — | 1 | 7.00 |
| CHEMBL4786409 | — | — | 1 | 6.92 |
| CHEMBL4798919 | — | — | 1 | 6.92 |
| CHEMBL4786627 | — | — | 1 | 6.89 |
| CHEMBL4782051 | — | — | 1 | 6.80 |
| CHEMBL4781286 | — | — | 1 | 6.80 |
| CHEMBL4277324 | — | — | 1 | 6.60 |
| CHEMBL1631694 | FEXINIDAZOLE | 4.0 | 1 | 6.22 |
| CHEMBL4795526 | — | — | 1 | 5.89 |
| CHEMBL4534157 | — | — | 1 | 5.89 |
| CHEMBL290960 | NIFURTIMOX | 4.0 | 1 | 5.58 |
| CHEMBL2441910 | — | — | 1 | 5.54 |
| CHEMBL4788481 | — | — | 1 | 5.17 |
| CHEMBL830 | EFLORNITHINE | 4.0 | 1 | 4.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL265502 | SURAMIN | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4779309 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4787217 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4780415 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4791697 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4786409 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4798919 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4786627 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4782051 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4781286 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4277324 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1631694 | FEXINIDAZOLE | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4795526 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4534157 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL290960 | NIFURTIMOX | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL2441910 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4788481 | — | EC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL830 | EFLORNITHINE | EC50 | = | 13300.0 | nM | 4.88 |