Assay Detail
Functional
CHEMBL2154428
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiparasitic activity against Trypanosoma brucei rhodesiense STIB900 bloodstream forms assessed as reduction in cell viability after 70 hrs by alamar blue assay
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
1-Aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 53 | 5.73 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 8.05 |
| CHEMBL2153241 | — | — | 1 | 7.00 |
| CHEMBL423172 | MEGAZOL | — | 1 | 7.00 |
| CHEMBL2153117 | — | — | 1 | 6.80 |
| CHEMBL2153237 | — | — | 1 | 6.31 |
| CHEMBL2153243 | — | — | 1 | 6.16 |
| CHEMBL2153242 | — | — | 1 | 6.16 |
| CHEMBL2153115 | — | — | 1 | 6.16 |
| CHEMBL2153105 | — | — | 1 | 6.14 |
| CHEMBL2153109 | — | — | 1 | 6.14 |
| CHEMBL2153108 | — | — | 1 | 6.14 |
| CHEMBL2153236 | — | — | 1 | 6.12 |
| CHEMBL2153113 | — | — | 1 | 6.11 |
| CHEMBL2153111 | — | — | 1 | 6.05 |
| CHEMBL2153251 | — | — | 1 | 6.03 |
| CHEMBL2153112 | — | — | 1 | 6.01 |
| CHEMBL2153245 | — | — | 1 | 6.00 |
| CHEMBL2153114 | — | — | 1 | 5.84 |
| CHEMBL2153234 | — | — | 1 | 5.79 |
| CHEMBL2153116 | — | — | 1 | 5.75 |
| CHEMBL2153118 | — | — | 1 | 5.74 |
| CHEMBL2153120 | — | — | 1 | 5.72 |
| CHEMBL2153238 | — | — | 1 | 5.72 |
| CHEMBL2153246 | — | — | 1 | 5.70 |
| CHEMBL2153248 | — | — | 1 | 5.67 |
| CHEMBL2153232 | — | — | 1 | 5.66 |
| CHEMBL2153106 | — | — | 1 | 5.60 |
| CHEMBL1631694 | FEXINIDAZOLE | 4.0 | 1 | 5.59 |
| CHEMBL2153104 | — | — | 1 | 5.54 |
| CHEMBL2153121 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2153241 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL423172 | MEGAZOL | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2153117 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2153237 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL2153243 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2153242 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2153115 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2153105 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL2153109 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL2153108 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL2153236 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL2153113 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL2153111 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL2153251 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL2153112 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL2153245 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL2153114 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL2153234 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL2153116 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL2153118 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL2153120 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL2153238 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2153246 | — | IC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL2153248 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL2153232 | — | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL2153106 | — | IC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL1631694 | FEXINIDAZOLE | IC50 | = | 2570.0 | nM | 5.59 |
| CHEMBL2153104 | — | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL2153121 | — | IC50 | = | 3190.0 | nM | 5.50 |
| CHEMBL830 | EFLORNITHINE | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL2153103 | — | IC50 | = | 4490.0 | nM | 5.35 |
| CHEMBL2153255 | — | IC50 | = | 11280.0 | nM | 4.95 |
| CHEMBL2153119 | — | IC50 | = | 11960.0 | nM | 4.92 |
| CHEMBL2153254 | — | IC50 | = | 11890.0 | nM | 4.92 |
| CHEMBL2153258 | — | IC50 | = | 20160.0 | nM | 4.70 |
| CHEMBL2151060 | — | IC50 | = | 20760.0 | nM | 4.68 |
| CHEMBL2153259 | — | IC50 | = | 23540.0 | nM | 4.63 |
| CHEMBL2153257 | — | IC50 | = | 27030.0 | nM | 4.57 |
| CHEMBL2153231 | — | IC50 | = | 28030.0 | nM | 4.55 |
| CHEMBL2153253 | — | IC50 | = | 95540.0 | nM | 4.02 |
| CHEMBL2153252 | — | IC50 | = | 141320.0 | nM | - |
| CHEMBL2153107 | — | IC50 | - | — | - | |
| CHEMBL2153110 | — | IC50 | - | — | - | |
| CHEMBL2153256 | — | IC50 | = | 124600.0 | nM | - |
| CHEMBL2153240 | — | IC50 | - | — | - | |
| CHEMBL2153250 | — | IC50 | - | — | - | |
| CHEMBL2153249 | — | IC50 | - | — | - | |
| CHEMBL2153247 | — | IC50 | - | — | - | |
| CHEMBL2153244 | — | IC50 | - | — | - |