Assay Detail
Functional
CHEMBL4155545
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against trypomastigote stage of Trypanosoma brucei brucei AnTat 1.9 assessed as decrease in parasite viability after 69 hrs by Alamar Blue assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel 8-nitroquinolin-2(1H)-ones as NTR-bioactivated antikinetoplastid molecules: Synthesis, electrochemical and SAR study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.36 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 7.70 |
| CHEMBL4161893 | — | — | 1 | 6.40 |
| CHEMBL1631694 | FEXINIDAZOLE | 4.0 | 1 | 6.40 |
| CHEMBL4172543 | — | — | 1 | 5.92 |
| CHEMBL4170207 | — | — | 1 | 5.72 |
| CHEMBL4170632 | — | — | 1 | 5.68 |
| CHEMBL2042585 | — | — | 1 | 5.64 |
| CHEMBL4162608 | — | — | 1 | 5.60 |
| CHEMBL3400775 | — | — | 1 | 5.26 |
| CHEMBL4167821 | — | — | 1 | 5.14 |
| CHEMBL4173976 | — | — | 1 | 5.12 |
| CHEMBL4174366 | — | — | 1 | 4.97 |
| CHEMBL222838 | EFLORNITHINE, (S)- | 2.0 | 1 | 4.80 |
| CHEMBL167727 | — | — | 1 | 4.75 |
| CHEMBL4167144 | — | — | 1 | 4.68 |
| CHEMBL2042573 | — | — | 1 | 4.63 |
| CHEMBL4177010 | — | — | 1 | 4.54 |
| CHEMBL2042574 | — | — | 1 | 4.54 |
| CHEMBL4170541 | — | — | 1 | 4.42 |
| CHEMBL4159984 | — | — | 1 | - |
| CHEMBL4168605 | — | — | 1 | - |
| CHEMBL4176469 | — | — | 1 | - |
| CHEMBL4165186 | — | — | 1 | - |
| CHEMBL4169157 | — | — | 1 | - |
| CHEMBL2042584 | — | — | 1 | - |
| CHEMBL216146 | — | — | 1 | - |
| CHEMBL186422 | — | — | 1 | - |
| CHEMBL4163695 | — | — | 1 | - |
| CHEMBL3601315 | — | — | 1 | - |
| CHEMBL15750 | NITROBENZENE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL265502 | SURAMIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4161893 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1631694 | FEXINIDAZOLE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4172543 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4170207 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4170632 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL2042585 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4162608 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3400775 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4167821 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4173976 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4174366 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL222838 | EFLORNITHINE, (S)- | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL167727 | — | IC50 | = | 17900.0 | nM | 4.75 |
| CHEMBL4167144 | — | IC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL2042573 | — | IC50 | = | 23400.0 | nM | 4.63 |
| CHEMBL4177010 | — | IC50 | = | 29100.0 | nM | 4.54 |
| CHEMBL2042574 | — | IC50 | = | 28500.0 | nM | 4.54 |
| CHEMBL4170541 | — | IC50 | = | 38300.0 | nM | 4.42 |
| CHEMBL4159984 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4168605 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4176469 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4165186 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4169157 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2042584 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL216146 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL186422 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4163695 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3601315 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL15750 | NITROBENZENE | IC50 | > | 50000.0 | nM | - |