Assay Detail

CHEMBL5576960

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Functional

Antitrypanosomal activity against Trypanosoma brucei rhodesiense

ChEMBL ↗

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Target

Trypanosoma brucei rhodesiense (CHEMBL612348) ↗

Open DB target context

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Trypanosoma brucei rhodesiense (CHEMBL612348) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Trypanosoma brucei rhodesiense

CHEMBL612348

Anchored from Assay target.

Protein identity Trypanosoma brucei rhodesiense

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Trypanosoma brucei rhodesiense
Confidence	1 — Organism
Curated By	Autocuration

Target

Trypanosoma brucei rhodesiense (CHEMBL612348) ↗

Type	ORGANISM
Organism	Trypanosoma brucei rhodesiense

Publication

Novel 4-[4-(4-methylpiperazin-1-yl)phenyl]-6-arylpyrimidine derivatives and their antitrypanosomal activities against T.brucei.

Taylor AE, Hering M, Elsegood MRJ, Teat SJ, Weaver GW, Arroo RRJ, Kaiser M, Maeser P, Bhambra AS.
Bioorg Med Chem Lett (2024) 109 : 129825 -129825
PubMed 38823730 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	6.12	6.12
EC90	1	-	-

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1631694	FEXINIDAZOLE	4.0	2	6.12

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1631694	FEXINIDAZOLE	EC50	=	760.0	nM	6.12
CHEMBL1631694	FEXINIDAZOLE	EC90	=	0.76	uM	-