Assay Detail
Functional
CHEMBL4771958
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Antileishmanial activity against Leishmania donovani MHOM/IN/00/DEVI promastigotes assessed as inhibition of metabolic activity measured after 72 hrs by MTT assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
8-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruzi.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 5.81 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 7.16 |
| CHEMBL4786627 | — | — | 1 | 6.00 |
| CHEMBL4534157 | — | — | 1 | 6.00 |
| CHEMBL4788481 | — | — | 1 | 6.00 |
| CHEMBL1631694 | FEXINIDAZOLE | 4.0 | 1 | 5.92 |
| CHEMBL4277324 | — | — | 1 | 5.92 |
| CHEMBL4782051 | — | — | 1 | 5.89 |
| CHEMBL4780415 | — | — | 1 | 5.80 |
| CHEMBL4781286 | — | — | 1 | 5.80 |
| CHEMBL4791697 | — | — | 1 | 5.77 |
| CHEMBL2441910 | — | — | 1 | 5.75 |
| CHEMBL4798919 | — | — | 1 | 5.52 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 5.51 |
| CHEMBL4786409 | — | — | 1 | 5.41 |
| CHEMBL4779309 | — | — | 1 | 5.33 |
| CHEMBL4787217 | — | — | 1 | 5.13 |
| CHEMBL4795526 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4786627 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4534157 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4788481 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1631694 | FEXINIDAZOLE | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4277324 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4782051 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4780415 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4781286 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4791697 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL2441910 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4798919 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL125 | MILTEFOSINE | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4786409 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4779309 | — | EC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4787217 | — | EC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4795526 | — | EC50 | > | 62500.0 | nM | - |