Assay Detail
Functional
CHEMBL4345836
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Antitrypanosomal activity against Trypanosoma brucei brucei AnTat 1.9 trypomastigotes assessed as reduction in parasite viability incubated for 69 hrs by Alamar Blue dye based assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New 8-Nitroquinolinone Derivative Displaying Submicromolar in Vitro Activities against Both Trypanosoma brucei and cruzi.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 6.21 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4565434 | — | — | 1 | 7.92 |
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 7.52 |
| CHEMBL4566278 | — | — | 1 | 7.30 |
| CHEMBL4575234 | — | — | 1 | 7.16 |
| CHEMBL4482886 | — | — | 1 | 7.00 |
| CHEMBL4559873 | — | — | 1 | 6.70 |
| CHEMBL4556532 | — | — | 1 | 6.70 |
| CHEMBL1631694 | FEXINIDAZOLE | 4.0 | 1 | 6.40 |
| CHEMBL4534870 | — | — | 1 | 6.24 |
| CHEMBL4449777 | — | — | 1 | 6.07 |
| CHEMBL4559890 | — | — | 1 | 6.00 |
| CHEMBL4172543 | — | — | 1 | 5.92 |
| CHEMBL4547155 | — | — | 1 | 5.82 |
| CHEMBL4445909 | — | — | 1 | 5.77 |
| CHEMBL4569720 | — | — | 1 | 5.06 |
| CHEMBL830 | EFLORNITHINE | 4.0 | 1 | 4.88 |
| CHEMBL4439484 | — | — | 1 | 4.68 |
| CHEMBL2042573 | — | — | 1 | 4.63 |
| CHEMBL4537323 | — | — | 1 | - |
| CHEMBL4588561 | — | — | 1 | - |
| CHEMBL4547753 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4565434 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL265502 | SURAMIN | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4566278 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4575234 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4482886 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4559873 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4556532 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1631694 | FEXINIDAZOLE | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4534870 | — | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL4449777 | — | EC50 | = | 850.0 | nM | 6.07 |
| CHEMBL4559890 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4172543 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4547155 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4445909 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4569720 | — | EC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL830 | EFLORNITHINE | EC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL4439484 | — | EC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL2042573 | — | EC50 | = | 23400.0 | nM | 4.63 |
| CHEMBL4537323 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4588561 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4547753 | — | EC50 | > | 50000.0 | nM | - |