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Target Snapshot

CHEMBL612849 Target Snapshot

Trypanosoma brucei · ORGANISM · Trypanosoma brucei

Back to Search Search this target Browse approvals Evidence Card
74,470Compounds
671Assays
34Approved Drugs
5,063.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Trypanosoma brucei as ChEMBL target CHEMBL612849. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Trypanosoma brucei
ORGANISM · Trypanosoma brucei
As of 2026-09-13
ChEMBL target ID
CHEMBL612849
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Trypanosoma brucei still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameTrypanosoma brucei
Target TypeORGANISM
OrganismTrypanosoma brucei
ChEMBL ↗ NCBI Taxonomy ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelTrypanosoma brucei
UniProt AccessionN/A

Trypanosoma brucei

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Trypanosoma brucei.

Review nameTrypanosoma brucei
OrganismTrypanosoma brucei
Clinical Profile

Clinical Phase Distribution

34
Approved
10
Phase III
18
Phase II
6
Phase I
Assay Mix

Activity Type Distribution

IC503,512.0
EC501,551.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5505832 10.96 IC50 0.011 Preclinical
CHEMBL4594805 10.15 IC50 0.07 Preclinical
CHEMBL25526 9.77 IC50 0.17 Preclinical
CHEMBL55 9.7 IC50 0.2 Approved
CHEMBL55 9.47 EC50 0.34 Approved
CHEMBL3357685 9.4 EC50 0.4 Clinical
CHEMBL5288670 9.4 IC50 0.4 Preclinical
CHEMBL5272888 9.4 IC50 0.4 Preclinical
CHEMBL3357697 9.3 EC50 0.5 Preclinical
CHEMBL3358120 9.22 EC50 0.6 Preclinical
Distribution

pChEMBL Value Distribution

536
5.0
468
5.5
456
6.0
350
6.5
191
7.0
111
7.5
73
8.0
26
8.5
19
9.0
3
9.5
pChEMBL
Approved Drugs

Approved Drugs

FEXINIDAZOLE
CHEMBL1631694
Approved 2021
Properties Compare Identifier
NIFURTIMOX
CHEMBL290960
Approved 2020
Properties Compare Identifier
BENZNIDAZOLE
CHEMBL110
Approved 2017
Properties Compare Identifier
PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
PENTAMIDINE
CHEMBL55
Approved 1984
Properties Compare Identifier
HALOPROGIN
CHEMBL1289
Approved 1982
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
NITROFURAZONE
CHEMBL869
Approved 1945
Properties Compare Identifier
EMETINE
CHEMBL50588
Properties Compare Identifier
Assay Landscape

Assay Landscape

681
Total Assays
2,242
Tested Compounds
2
Assay Types
Functional — 675 assays, 2,242 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 651 2,102 5.9
assay format 24 140 5.4
ADME — 6 assays, 10 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 5 10 5.8
assay format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine