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Evidence Snapshot

Trypanosoma brucei

CHEMBL612849 ORGANISM Trypanosoma brucei
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T21:25:43Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL612849
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Trypanosoma brucei as ChEMBL target CHEMBL612849. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Trypanosoma brucei
ORGANISM · Trypanosoma brucei
As of 2026-09-13
ChEMBL target ID
CHEMBL612849
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Trypanosoma brucei matters

As of 2026-09-13

Trypanosoma brucei is reviewed as Trypanosoma brucei; the current evidence base includes 34 approved drugs, 74470 compounds, and 671 assays, with lead potency reaching pChEMBL 11.0.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 34 approved drugs, 74470 compounds, and 671 assays for this target. The dominant activity type is IC50. CHEMBL5505832 is the current potency anchor at pChEMBL 11.0.

Use CHEMBL5505832 as the tractability anchor when discussing potency (pChEMBL 11.0).

Activity source · ChEMBL 36 via Core Engine
34 approved pChEMBL 11.0
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Trypanosoma brucei matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

74470
Total Compounds
671
Total Assays
34
Approved Drugs
IC50: 3512.0, EC50: 1551.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL5505832
 11.0 IC50 —
No preferred name
CHEMBL4594805
 10.2 IC50 —
No preferred name
CHEMBL25526
 9.8 IC50 —
No preferred name
CHEMBL55
 9.7 IC50 Approved
No preferred name
CHEMBL55
 9.5 EC50 Approved

Approved Drugs

Structure Compound First Approval
FEXINIDAZOLE
CHEMBL1631694
 2021
NIFURTIMOX
CHEMBL290960
 2020
BENZNIDAZOLE
CHEMBL110
 2017
PACLITAXEL
CHEMBL428647
 1992
PENTAMIDINE
CHEMBL55
 1984
HALOPROGIN
CHEMBL1289
 1982
VINBLASTINE
CHEMBL159
 1965
NITROFURAZONE
CHEMBL869
 1945
EMETINE
CHEMBL50588
 —
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Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T21:25:43Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL612849