Compound Detail
CHEMBL869
NITROFURAZONE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL869 |
| Name | NITROFURAZONE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | IAIWVQXQOWNYOU-FPYGCLRLSA-N |
| Therapeutic | ✓ Yes |
6
Targets
20
Activities
3
Assay Types
0
PK Parameters
20
Publications
7
Known Names
5
Indications
1
Mechanisms
Molecular Properties
198.1
MW (Da)
0.19
ALogP
5
HBA
2
HBD
123.8
PSA (Ų)
0.41
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1945 |
| Availability | Withdrawn |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| DNA inhibitor | INHIBITOR | DNA | ✓ | ✓ |
Indications
Eye Infections Leishmaniasis Trypanosomiasis Amyotrophic Lateral Sclerosis Osteomyelitis
ATC Classification
B05CA03
nitrofural
Level 1: BLOOD AND BLOOD FORMING ORGANS
Level 2: BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
D08AF01
nitrofural
Level 1: DERMATOLOGICALS
Level 2: ANTISEPTICS AND DISINFECTANTS
D09AA03
nitrofural
Level 1: DERMATOLOGICALS
Level 2: MEDICATED DRESSINGS
P01CC02
nitrofural
Level 1: ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
Level 2: ANTIPROTOZOALS
S01AX04
nitrofural
Level 1: SENSORY ORGANS
Level 2: OPHTHALMOLOGICALS
S02AA02
nitrofural
Level 1: SENSORY ORGANS
Level 2: OTOLOGICALS
Drug Warnings
Withdrawn
General Warning
superseded by safer and more effective preparations
Withdrawn
carcinogenicity
mammary tumors in rats and ovarian tumors in mice
Activity Summary
IC50 15 meas. best 5.77
EC50 4 meas. best 6.51
Ki 1 meas.
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Trypanosoma brucei CHEMBL612849 | EC50 | 6.51 | 5.79 | 310.0 | 3 |
| Leishmania donovani CHEMBL367 | IC50 | 5.77 | 5.638 | 1690.0 | 5 |
| Leishmania major CHEMBL612879 | IC50 | 5.73 | 5.565 | 1850.0 | 4 |
| Trypanosoma cruzi CHEMBL368 | IC50 | 5.65 | 5.38 | 2230.0 | 2 |
| Trypanosoma cruzi CHEMBL368 | EC50 | 5.1 | 5.1 | 8000.0 | 1 |
| Snake venom metalloproteinase BaP1 CHEMBL2079851 | IC50 | 4.05 | 4.05 | 88100.0 | 1 |
| NAD(+) hydrolase SARM1 CHEMBL4523350 | IC50 | 4.05 | 4.05 | 90000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine