NAD(+) hydrolase SARM1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q6SZW1. Use UniProt Q6SZW1 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q6SZW1 as the stable identity anchor, then attach disease evidence before program review.
NAD(+) hydrolase SARM1
Review this target as NAD(+) hydrolase SARM1, mapped to UniProt Q6SZW1. Sequence length is 724 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats NAD(+) hydrolase SARM1 as ChEMBL target CHEMBL4523350, mapped to UniProt Q6SZW1. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | NAD(+) hydrolase SARM1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q6SZW1 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | NAD(+) hydrolase SARM1 |
| UniProt Accession | Q6SZW1 |
| Component Type | Protein |
| Sequence Length | 724 aa |
NAD(+) hydrolase SARM1
Review this target as NAD(+) hydrolase SARM1, mapped to UniProt Q6SZW1. Sequence length is 724 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2009370 | 6.82 | IC50 | 150.0 | Preclinical |
| CHEMBL2009483 | 6.16 | IC50 | 700.0 | Preclinical |
| CHEMBL1219 | 5.5 | IC50 | 3200.0 | Approved |
| CHEMBL1201863 | 5.48 | IC50 | 3300.0 | Approved |
| CHEMBL1475252 | 5.13 | IC50 | 7400.0 | Clinical |
| CHEMBL4458111 | 4.67 | IC50 | 21400.0 | Preclinical |
| CHEMBL1140 | 4.36 | IC50 | 43800.0 | Approved |
| CHEMBL1201022 | 4.16 | Ki | 70000.0 | Approved |
| CHEMBL12089 | 4.11 | IC50 | 77000.0 | Preclinical |
| CHEMBL869 | 4.05 | IC50 | 90000.0 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 13 | 7 | 5.3 |
| subcellular format | 6 | 4 | 4.1 |
| single protein format | 1 | 1 | — |