Compound Detail
CHEMBL1219
RABEPRAZOLE 💊 Approved Drug
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1219 |
| Name | RABEPRAZOLE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | YREYEVIYCVEVJK-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
17
Targets
24
Activities
2
Assay Types
8
PK Parameters
20
Publications
8
Known Names
13
Indications
Molecular Properties
359.4
MW (Da)
2.99
ALogP
5
HBA
1
HBD
83.1
PSA (Ų)
0.49
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1999 |
| Availability | Prescription |
| Chirality | Racemic |
Indications
Gastroesophageal Reflux Peptic Ulcer Duodenal Ulcer Gastrointestinal Hemorrhage Helicobacter Infections Dyspepsia Amyotrophic Lateral Sclerosis Cholangiocarcinoma Communicable Diseases Hematologic Neoplasms Lymphoma Neoplasms Neoplasms
ATC Classification
A02BC04
rabeprazole
Level 1: ALIMENTARY TRACT AND METABOLISM
Level 2: DRUGS FOR ACID RELATED DISORDERS
A02BC54
rabeprazole, combinations
Level 1: ALIMENTARY TRACT AND METABOLISM
Level 2: DRUGS FOR ACID RELATED DISORDERS
Activity Summary
IC50 20 meas. best 7.74
Ki 4 meas. best 6.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Giardia intestinalis CHEMBL612652 | IC50 | 7.74 | 7.74 | 18.1 | 1 |
| Entamoeba histolytica CHEMBL612853 | IC50 | 7.62 | 7.62 | 23.7 | 1 |
| Trichomonas vaginalis CHEMBL612884 | IC50 | 6.98 | 6.98 | 105.7 | 2 |
| Urease subunit alpha/Urease subunit beta CHEMBL3885651 | IC50 | 6.54 | 6.54 | 290.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 6.52 | 6.08 | 300.0 | 2 |
| Histone-lysine N-methyltransferase 2A/WDR5 CHEMBL3883320 | IC50 | 6.31 | 6.31 | 490.0 | 1 |
| D(3) dopamine receptor CHEMBL234 | Ki | 6.1 | 6.1 | 790.0 | 1 |
| Alpha-2B adrenergic receptor CHEMBL1942 | Ki | 6.1 | 6.1 | 793.0 | 1 |
| Alpha-2B adrenergic receptor CHEMBL1942 | IC50 | 5.76 | 5.76 | 1737.0 | 1 |
| Adenosine receptor A3 CHEMBL256 | Ki | 5.74 | 5.74 | 1820.0 | 1 |
| D(3) dopamine receptor CHEMBL234 | IC50 | 5.63 | 5.63 | 2326.0 | 1 |
| NAD(+) hydrolase SARM1 CHEMBL4523350 | IC50 | 5.5 | 5.49 | 3200.0 | 2 |
| Adenosine receptor A3 CHEMBL256 | IC50 | 5.49 | 5.49 | 3219.0 | 1 |
| Cytosolic endo-beta-N-acetylglucosaminidase CHEMBL5172 | IC50 | 5.35 | 5.35 | 4470.0 | 1 |
| Fatty acid synthase CHEMBL4158 | Ki | 5.23 | 5.23 | 5900.0 | 1 |
| Plasmodium falciparum CHEMBL364 | IC50 | 5.16 | 5.16 | 7000.0 | 1 |
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 5.1 | 5.1 | 7880.0 | 1 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 CHEMBL5393 | IC50 | 5.07 | 5.07 | 8500.0 | 1 |
| Insulin-degrading enzyme CHEMBL1293287 | IC50 | 4.96 | 4.96 | 11000.0 | 1 |
| N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 CHEMBL6036 | IC50 | 4.28 | 4.28 | 53000.0 | 1 |
| Fatty acid synthase CHEMBL4158 | IC50 | 4.28 | 4.28 | 52000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 4.0 | mL.min-1.kg-1 | Homo sapiens |
| CL | 4.0 | mL.min-1.kg-1 | Homo sapiens |
| CL | 4.0 | mL.min-1.kg-1 | Homo sapiens |
| CL | 4.0 | mL.min-1.kg-1 | Homo sapiens |
| Fu | 0.037 | - | Homo sapiens |
| Fu | 0.037 | - | Homo sapiens |
| MRT | 0.92 | hr | Homo sapiens |
| T1/2 | 1.0 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine