Assay Detail
Functional
CHEMBL1924445
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Antiprotozoan activity against Entamoeba histolytica HM1-IMSS trophozoites compound treated for 48 hrs measured after 48 hrs washout period
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Entamoeba histolytica |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiprotozoal activity of proton-pump inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.73 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1502 | PANTOPRAZOLE | 4.0 | 1 | 8.59 |
| CHEMBL1219 | RABEPRAZOLE | 4.0 | 1 | 7.62 |
| CHEMBL69098 | — | — | 1 | 7.41 |
| CHEMBL480 | LANSOPRAZOLE | 4.0 | 1 | 6.46 |
| CHEMBL137 | METRONIDAZOLE | 4.0 | 1 | 6.46 |
| CHEMBL1503 | OMEPRAZOLE | 4.0 | 1 | 6.31 |
| CHEMBL1483 | ALBENDAZOLE | 4.0 | 1 | 4.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1502 | PANTOPRAZOLE | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL1219 | RABEPRAZOLE | IC50 | = | 23.7 | nM | 7.62 |
| CHEMBL69098 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL480 | LANSOPRAZOLE | IC50 | = | 346.6 | nM | 6.46 |
| CHEMBL137 | METRONIDAZOLE | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL1503 | OMEPRAZOLE | IC50 | = | 492.2 | nM | 6.31 |
| CHEMBL1483 | ALBENDAZOLE | IC50 | = | 56330.0 | nM | 4.25 |