Compound Detail
CHEMBL1502
PANTOPRAZOLE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1502 |
| Name | PANTOPRAZOLE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | IQPSEEYGBUAQFF-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
14
Targets
22
Activities
2
Assay Types
16
PK Parameters
20
Publications
17
Known Names
20
Indications
Molecular Properties
383.4
MW (Da)
2.88
ALogP
6
HBA
1
HBD
92.3
PSA (Ų)
0.63
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2000 |
| Availability | Prescription |
| Chirality | Racemic |
Indications
Barrett Esophagus Diabetes Mellitus Esophageal Diseases Gastroesophageal Reflux Gastrointestinal Hemorrhage Heart Failure Hemorrhage Laryngopharyngeal Reflux Peptic Ulcer Ulcer Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Esophagitis Gastrinoma Helicobacter Infections Prostatic Neoplasms, Castration-Resistant Psychotic Disorders Schizophrenia Zollinger-Ellison Syndrome Acute Coronary Syndrome
ATC Classification
A02BC02
pantoprazole
Level 1: ALIMENTARY TRACT AND METABOLISM
Level 2: DRUGS FOR ACID RELATED DISORDERS
Activity Summary
IC50 21 meas. best 8.59
Ki 1 meas. best 5.39
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Entamoeba histolytica CHEMBL612853 | IC50 | 8.59 | 8.59 | 2.6 | 1 |
| Giardia intestinalis CHEMBL612652 | IC50 | 7.8 | 7.8 | 15.7 | 1 |
| Trichomonas vaginalis CHEMBL612884 | IC50 | 7.12 | 7.12 | 75.6 | 2 |
| Potassium-transporting ATPase CHEMBL2095173 | IC50 | 6.0 | 6.0 | 1000.0 | 1 |
| Solute carrier family 22 member 2 CHEMBL1743122 | IC50 | 5.82 | 5.82 | 1500.0 | 1 |
| Multidrug and toxin extrusion protein 1 CHEMBL1743126 | IC50 | 5.55 | 5.1567 | 2800.0 | 3 |
| Fatty acid synthase CHEMBL4158 | Ki | 5.39 | 5.39 | 4100.0 | 1 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 CHEMBL5393 | IC50 | 5.26 | 5.13 | 5500.0 | 2 |
| Indoleamine 2,3-dioxygenase 2 CHEMBL2189159 | IC50 | 4.9 | 4.9 | 12600.0 | 1 |
| ATP-dependent translocase ABCB1 CHEMBL4302 | IC50 | 4.75 | 4.75 | 17900.0 | 1 |
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 4.73 | 4.73 | 18510.0 | 1 |
| Fatty acid synthase CHEMBL4158 | IC50 | 4.44 | 4.44 | 36200.0 | 1 |
| Plasmodium falciparum CHEMBL364 | IC50 | 4.41 | 4.41 | 39000.0 | 1 |
| Multidrug and toxin extrusion protein 2 CHEMBL1743127 | IC50 | 4.37 | 4.37 | 43200.0 | 1 |
| N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 CHEMBL6036 | IC50 | 4.2 | 4.2 | 63000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 2.2 | mL.min-1.kg-1 | Homo sapiens |
| CL | 2.2 | mL.min-1.kg-1 | Homo sapiens |
| CL | 2.2 | mL.min-1.kg-1 | Homo sapiens |
| CL | 2.2 | mL.min-1.kg-1 | Homo sapiens |
| Cmax | 5450.0 | nM | Homo sapiens |
| F | 77.0 | % | Homo sapiens |
| F | 77.0 | % | Homo sapiens |
| Fu | 0.38 | - | Homo sapiens |
| Fu | 0.02 | - | Homo sapiens |
| MRT | 1.9 | hr | Homo sapiens |
| T1/2 | 0.15 | hr | - |
| T1/2 | 3.0 | hr | - |
| T1/2 | 130.0 | hr | - |
| T1/2 | 1.17 | hr | - |
| T1/2 | 23.11 | hr | - |
| T1/2 | 1.9 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine