Assay Detail
Binding
CHEMBL2210857
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Inhibition of mouse Ido2 transfected in HEK293T cells using L-tryptophan as substrate assessed as kynurenine formation after 45 mins by spectrophotometric analysis
13
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of selective inhibitors of indoleamine 2,3-dioxygenase 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.17 | 5.82 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL193 | NIFEDIPINE | 4.0 | 1 | 5.82 |
| CHEMBL1475252 | TENATOPRAZOLE | 2.0 | 1 | 5.75 |
| CHEMBL408 | TROGLITAZONE | 4.0 | 1 | 5.35 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 5.35 |
| CHEMBL104 | CLOTRIMAZOLE | 4.0 | 1 | 5.23 |
| CHEMBL91 | MICONAZOLE | 4.0 | 1 | 5.17 |
| CHEMBL808 | ECONAZOLE | 4.0 | 1 | 5.12 |
| CHEMBL480 | LANSOPRAZOLE | 4.0 | 1 | 5.09 |
| CHEMBL1221 | SULCONAZOLE | 4.0 | 1 | 5.00 |
| CHEMBL1502 | PANTOPRAZOLE | 4.0 | 1 | 4.90 |
| CHEMBL7301 | FENRETINIDE | 3.0 | 1 | 4.73 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 4.54 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL193 | NIFEDIPINE | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1475252 | TENATOPRAZOLE | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL408 | TROGLITAZONE | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL192 | SILDENAFIL | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL104 | CLOTRIMAZOLE | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL91 | MICONAZOLE | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL808 | ECONAZOLE | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL480 | LANSOPRAZOLE | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL1221 | SULCONAZOLE | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL1502 | PANTOPRAZOLE | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL7301 | FENRETINIDE | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL38 | TRETINOIN | IC50 | = | 28700.0 | nM | 4.54 |
| CHEMBL157101 | KETOCONAZOLE | Inhibition | - | % | - |