Assay Detail
Functional
CHEMBL2077342
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TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 5 uM) in Caco-2 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | Caco-2 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Interaction of omeprazole, lansoprazole and pantoprazole with P-glycoprotein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.57 | 4.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1503 | OMEPRAZOLE | 4.0 | 1 | 4.75 |
| CHEMBL1502 | PANTOPRAZOLE | 4.0 | 1 | 4.75 |
| CHEMBL480 | LANSOPRAZOLE | 4.0 | 1 | 4.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1503 | OMEPRAZOLE | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL1502 | PANTOPRAZOLE | IC50 | = | 17900.0 | nM | 4.75 |
| CHEMBL480 | LANSOPRAZOLE | IC50 | = | 62800.0 | nM | 4.20 |