Assay Detail
Functional
CHEMBL1924296
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Antiprotozoan activity against Giardia intestinalis IMSS:0989:1 trophozoites compound treated for 48 hrs measured after 48 hrs washout period
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Giardia intestinalis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiprotozoal activity of proton-pump inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.17 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1502 | PANTOPRAZOLE | 4.0 | 1 | 7.80 |
| CHEMBL1219 | RABEPRAZOLE | 4.0 | 1 | 7.74 |
| CHEMBL1483 | ALBENDAZOLE | 4.0 | 1 | 7.43 |
| CHEMBL480 | LANSOPRAZOLE | 4.0 | 1 | 7.14 |
| CHEMBL1503 | OMEPRAZOLE | 4.0 | 1 | 7.02 |
| CHEMBL137 | METRONIDAZOLE | 4.0 | 1 | 5.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1502 | PANTOPRAZOLE | IC50 | = | 15.7 | nM | 7.80 |
| CHEMBL1219 | RABEPRAZOLE | IC50 | = | 18.1 | nM | 7.74 |
| CHEMBL1483 | ALBENDAZOLE | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL480 | LANSOPRAZOLE | IC50 | = | 73.1 | nM | 7.14 |
| CHEMBL1503 | OMEPRAZOLE | IC50 | = | 95.5 | nM | 7.02 |
| CHEMBL137 | METRONIDAZOLE | IC50 | = | 1226.0 | nM | 5.91 |