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Target Snapshot

CHEMBL612652 Target Snapshot

Giardia intestinalis · ORGANISM · Giardia intestinalis

689Compounds
169Assays
20Approved Drugs
1,023.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Giardia intestinalis as ChEMBL target CHEMBL612652. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Giardia intestinalis
ORGANISM · Giardia intestinalis
As of 2026-09-14
ChEMBL target ID
CHEMBL612652
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Giardia intestinalis still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelGiardia intestinalis
UniProt AccessionN/A

Giardia intestinalis

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Giardia intestinalis.

Review nameGiardia intestinalis
OrganismGiardia intestinalis
Clinical Profile

Clinical Phase Distribution

20
Approved
1
Phase III
5
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC50871.0
EC50152.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4793489 8.52 IC50 3.0 Preclinical
CHEMBL1170157 8.3 IC50 5.0 Preclinical
CHEMBL71936 8.3 IC50 5.0 Preclinical
CHEMBL1223560 8.1 IC50 8.0 Preclinical
CHEMBL306226 8.1 IC50 8.0 Preclinical
CHEMBL4206155 8.1 IC50 7.9 Preclinical
CHEMBL506970 8.09 EC50 8.128 Preclinical
CHEMBL2403423 8.08 IC50 8.3 Preclinical
CHEMBL3114400 8.0 IC50 10.0 Preclinical
CHEMBL4779560 8.0 IC50 10.0 Preclinical
Distribution

pChEMBL Value Distribution

119
5.0
127
5.5
110
6.0
111
6.5
202
7.0
54
7.5
16
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

VORINOSTAT
CHEMBL98
Approved 2006
TINIDAZOLE
CHEMBL1220
Approved 2004
NITAZOXANIDE
CHEMBL1401
Approved 2002
PANTOPRAZOLE
CHEMBL1502
Approved 2000
RABEPRAZOLE
CHEMBL1219
Approved 1999
ALBENDAZOLE
CHEMBL1483
Approved 1996
LANSOPRAZOLE
CHEMBL480
Approved 1995
OMEPRAZOLE
CHEMBL1503
Approved 1989
MEBENDAZOLE
CHEMBL685
Approved 1974
METRONIDAZOLE
CHEMBL137
Approved 1963
DISULFIRAM
CHEMBL964
Approved 1951
CHLOROQUINE
CHEMBL76
Approved 1949
Assay Landscape

Assay Landscape

169
Total Assays
512
Tested Compounds
1
Assay Types
Functional — 169 assays, 512 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 163 500 6.2
assay format 6 12 5.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine