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Compound Detail

CHEMBL3114400

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COC(=O)Nc1ncc([N+](=O)[O-])s1

Basic Information

ChEMBL ID CHEMBL3114400
Phase Preclinical
Structure Type MOL
InChI Key RRFKBXJQFBLCHO-UHFFFAOYSA-N
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

203.2
MW (Da)
1.23
ALogP
6
HBA
1
HBD
94.4
PSA (Ų)
0.58
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C5H5N3O4S
MW 203.18
Aromatic Rings 1
Heavy Atoms 13
NP-Likeness -2.39

Activity Summary

IC50 4 meas. best 8.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Giardia intestinalis
CHEMBL612652
IC50 8.0 8.0 10.0 2
Trichomonas vaginalis
CHEMBL612884
IC50 7.09 7.045 81.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
24529307 10.1016/j.bmc.2014.01.029 Trichomonas vaginalis 3
24529307 10.1016/j.bmc.2014.01.029 Giardia intestinalis 3
24529307 10.1016/j.bmc.2014.01.029 Unchecked 2
24529307 10.1016/j.bmc.2014.01.029 Vero 1
24529307 10.1016/j.bmc.2014.01.029 Trypanosoma cruzi 1
24529307 10.1016/j.bmc.2014.01.029 Leishmania amazonensis 1

Data from ChEMBL 36 via Core Engine