Assay Detail
Binding
CHEMBL1909215
Review assay metadata, readout intent, target linkage, and publication context from the same page.
DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA)
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
DrugMatrix in vitro pharmacology data
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 871 | 5.46 | 7.02 |
| Ki | 871 | 5.71 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12131 | CLOSANTEL | 2.0 | 2 | 7.27 |
| CHEMBL1289 | HALOPROGIN | 4.0 | 2 | 6.90 |
| CHEMBL508112 | BENZOTHIAZYL DISULFIDE | — | 2 | 6.71 |
| CHEMBL964 | DISULFIRAM | 4.0 | 2 | 6.70 |
| CHEMBL787 | MONTELUKAST | 4.0 | 2 | 6.61 |
| CHEMBL6067487 | IVERMECTIN | 4.0 | 2 | 6.54 |
| CHEMBL1262 | OXICONAZOLE | 4.0 | 2 | 6.45 |
| CHEMBL496 | HEXACHLOROPHENE | 4.0 | 2 | 6.44 |
| CHEMBL290106 | BITHIONOL | 4.0 | 2 | 6.33 |
| CHEMBL3215298 | ABAMECTIN | 3.0 | 2 | 6.31 |
| CHEMBL86754 | IODOQUINOL | 2.0 | 2 | 6.28 |
| CHEMBL1386 | TRANSPLATIN | 3.0 | 2 | 6.25 |
| CHEMBL1480 | FELODIPINE | 4.0 | 2 | 6.22 |
| CHEMBL1016 | CANDESARTAN | 3.0 | 2 | 6.16 |
| CHEMBL603 | ZAFIRLUKAST | 4.0 | 2 | 6.11 |
| CHEMBL306043 | GOLD SODIUM THIOMALATE | 2.0 | 2 | 6.07 |
| CHEMBL1366 | AURANOFIN | 4.0 | 2 | 6.02 |
| CHEMBL153062 | 4-NONYLPHENOL | — | 2 | 5.97 |
| CHEMBL411 | DIETHYLSTILBESTROL | 4.0 | 2 | 5.90 |
| CHEMBL1221 | SULCONAZOLE | 4.0 | 2 | 5.83 |
| CHEMBL91 | MICONAZOLE | 4.0 | 2 | 5.80 |
| CHEMBL7002 | CIGLITAZONE | 2.0 | 2 | 5.76 |
| CHEMBL305660 | EBASTINE | 4.0 | 2 | 5.74 |
| CHEMBL808 | ECONAZOLE | 4.0 | 2 | 5.74 |
| CHEMBL1219 | RABEPRAZOLE | 4.0 | 2 | 5.74 |
| CHEMBL508338 | THIMEROSAL | 3.0 | 2 | 5.72 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 2 | 5.68 |
| CHEMBL404849 | SULOCTIDIL | 4.0 | 2 | 5.68 |
| CHEMBL460291 | LACIDIPINE | 3.0 | 2 | 5.64 |
| CHEMBL64894 | GENTIAN VIOLET | 4.0 | 2 | 5.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12131 | CLOSANTEL | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL12131 | CLOSANTEL | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL1289 | HALOPROGIN | Ki | = | 126.0 | nM | 6.90 |
| CHEMBL508112 | BENZOTHIAZYL DISULFIDE | Ki | = | 196.0 | nM | 6.71 |
| CHEMBL964 | DISULFIRAM | Ki | = | 201.0 | nM | 6.70 |
| CHEMBL1289 | HALOPROGIN | IC50 | = | 223.0 | nM | 6.65 |
| CHEMBL787 | MONTELUKAST | Ki | = | 245.0 | nM | 6.61 |
| CHEMBL6067487 | IVERMECTIN | Ki | = | 289.4 | nM | 6.54 |
| CHEMBL508112 | BENZOTHIAZYL DISULFIDE | IC50 | = | 347.0 | nM | 6.46 |
| CHEMBL1262 | OXICONAZOLE | Ki | = | 358.6 | nM | 6.45 |
| CHEMBL964 | DISULFIRAM | IC50 | = | 356.0 | nM | 6.45 |
| CHEMBL496 | HEXACHLOROPHENE | Ki | = | 361.1 | nM | 6.44 |
| CHEMBL787 | MONTELUKAST | IC50 | = | 434.0 | nM | 6.36 |
| CHEMBL290106 | BITHIONOL | Ki | = | 468.0 | nM | 6.33 |
| CHEMBL3215298 | ABAMECTIN | Ki | = | 492.0 | nM | 6.31 |
| CHEMBL6067487 | IVERMECTIN | IC50 | = | 512.1 | nM | 6.29 |
| CHEMBL86754 | IODOQUINOL | Ki | = | 527.0 | nM | 6.28 |
| CHEMBL1386 | TRANSPLATIN | Ki | = | 559.0 | nM | 6.25 |
| CHEMBL1480 | FELODIPINE | Ki | = | 597.0 | nM | 6.22 |
| CHEMBL1262 | OXICONAZOLE | IC50 | = | 634.5 | nM | 6.20 |
| CHEMBL496 | HEXACHLOROPHENE | IC50 | = | 638.9 | nM | 6.20 |
| CHEMBL1016 | CANDESARTAN | Ki | = | 689.5 | nM | 6.16 |
| CHEMBL603 | ZAFIRLUKAST | Ki | = | 770.0 | nM | 6.11 |
| CHEMBL290106 | BITHIONOL | IC50 | = | 829.0 | nM | 6.08 |
| CHEMBL306043 | GOLD SODIUM THIOMALATE | Ki | = | 843.0 | nM | 6.07 |
| CHEMBL3215298 | ABAMECTIN | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL86754 | IODOQUINOL | IC50 | = | 933.0 | nM | 6.03 |
| CHEMBL1366 | AURANOFIN | Ki | = | 954.0 | nM | 6.02 |
| CHEMBL1386 | TRANSPLATIN | IC50 | = | 989.1 | nM | 6.00 |
| CHEMBL1480 | FELODIPINE | IC50 | = | 1057.0 | nM | 5.98 |
| CHEMBL153062 | 4-NONYLPHENOL | Ki | = | 1082.0 | nM | 5.97 |
| CHEMBL1016 | CANDESARTAN | IC50 | = | 1219.9 | nM | 5.91 |
| CHEMBL411 | DIETHYLSTILBESTROL | Ki | = | 1248.0 | nM | 5.90 |
| CHEMBL603 | ZAFIRLUKAST | IC50 | = | 1363.0 | nM | 5.87 |
| CHEMBL1221 | SULCONAZOLE | Ki | = | 1485.0 | nM | 5.83 |
| CHEMBL306043 | GOLD SODIUM THIOMALATE | IC50 | = | 1492.0 | nM | 5.83 |
| CHEMBL91 | MICONAZOLE | Ki | = | 1589.0 | nM | 5.80 |
| CHEMBL1366 | AURANOFIN | IC50 | = | 1688.0 | nM | 5.77 |
| CHEMBL7002 | CIGLITAZONE | Ki | = | 1722.0 | nM | 5.76 |
| CHEMBL1219 | RABEPRAZOLE | Ki | = | 1820.0 | nM | 5.74 |
| CHEMBL808 | ECONAZOLE | Ki | = | 1836.0 | nM | 5.74 |
| CHEMBL305660 | EBASTINE | Ki | = | 1806.1 | nM | 5.74 |
| CHEMBL508338 | THIMEROSAL | Ki | = | 1914.0 | nM | 5.72 |
| CHEMBL153062 | 4-NONYLPHENOL | IC50 | = | 1915.0 | nM | 5.72 |
| CHEMBL83 | TAMOXIFEN | Ki | = | 2092.0 | nM | 5.68 |
| CHEMBL404849 | SULOCTIDIL | Ki | = | 2094.6 | nM | 5.68 |
| CHEMBL411 | DIETHYLSTILBESTROL | IC50 | = | 2208.0 | nM | 5.66 |
| CHEMBL460291 | LACIDIPINE | Ki | = | 2281.0 | nM | 5.64 |
| CHEMBL64894 | GENTIAN VIOLET | Ki | = | 2355.0 | nM | 5.63 |
| CHEMBL547 | ISOTRETINOIN | Ki | = | 2357.0 | nM | 5.63 |