Compound Detail
CHEMBL404849
SULOCTIDIL 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL404849 |
| Name | SULOCTIDIL |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | BFCDFTHTSVTWOG-UHFFFAOYSA-N |
22
Targets
55
Activities
3
Assay Types
0
PK Parameters
20
Publications
21
Known Names
1
Indications
1
Mechanisms
Molecular Properties
337.6
MW (Da)
5.56
ALogP
3
HBA
2
HBD
32.3
PSA (Ų)
0.39
QED
1
Ro5 Violations
12
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1979 |
| Availability | Withdrawn |
| Chirality | Racemic |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Voltage-gated calcium channel blocker | BLOCKER | Voltage-gated calcium channel | ✓ | ✓ |
Indications
Cardiovascular Diseases
ATC Classification
C04AX19
suloctidil
Level 1: CARDIOVASCULAR SYSTEM
Level 2: PERIPHERAL VASODILATORS
Drug Warnings
Withdrawn
hepatotoxicity
Hepatotoxicity
Withdrawn
hepatotoxicity
Hepatotoxicity
Withdrawn
hepatotoxicity
hepatitis
Withdrawn
hepatotoxicity
hepatitis
Activity Summary
IC50 29 meas. best 7.67
Ki 24 meas. best 7.88
EC50 2 meas. best 7.08
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | Ki | 7.88 | 6.835 | 13.2 | 6 |
| Unchecked CHEMBL612545 | IC50 | 7.67 | 6.0044 | 21.4 | 9 |
| Sigma non-opioid intracellular receptor 1 CHEMBL287 | Ki | 7.31 | 7.31 | 49.3 | 1 |
| Plasmodium falciparum CHEMBL364 | EC50 | 7.08 | 6.65 | 82.4 | 2 |
| Histamine H2 receptor CHEMBL1941 | Ki | 7.05 | 7.05 | 88.5 | 1 |
| Histamine H2 receptor CHEMBL1941 | IC50 | 6.97 | 6.97 | 108.1 | 1 |
| Sigma non-opioid intracellular receptor 1 CHEMBL287 | IC50 | 6.93 | 6.93 | 117.2 | 1 |
| 5-hydroxytryptamine receptor 1A CHEMBL273 | Ki | 6.51 | 6.51 | 310.6 | 1 |
| Alpha-2C adrenergic receptor CHEMBL1916 | Ki | 6.3 | 6.3 | 500.7 | 1 |
| 5-hydroxytryptamine receptor 1A CHEMBL273 | IC50 | 6.26 | 6.26 | 543.5 | 1 |
| 5-hydroxytryptamine receptor 2B CHEMBL1833 | Ki | 6.22 | 6.22 | 597.5 | 1 |
| Muscarinic acetylcholine receptor M4 CHEMBL1821 | Ki | 6.2 | 6.2 | 636.1 | 1 |
| Sodium-dependent serotonin transporter CHEMBL228 | Ki | 6.18 | 6.18 | 665.8 | 1 |
| D(3) dopamine receptor CHEMBL234 | Ki | 6.15 | 6.15 | 714.5 | 1 |
| Tyrosine-protein kinase Fyn CHEMBL1841 | IC50 | 6.14 | 6.14 | 722.1 | 1 |
| Alpha-2A adrenergic receptor CHEMBL1867 | Ki | 6.12 | 6.12 | 758.7 | 1 |
| Epidermal growth factor receptor CHEMBL203 | IC50 | 6.1 | 6.1 | 794.4 | 1 |
| 5-hydroxytryptamine receptor 2B CHEMBL1833 | IC50 | 6.03 | 6.03 | 939.0 | 1 |
| Muscarinic acetylcholine receptor M3 CHEMBL245 | Ki | 6.01 | 6.01 | 980.0 | 1 |
| Muscarinic acetylcholine receptor M1 CHEMBL216 | Ki | 5.96 | 5.96 | 1085.0 | 1 |
| Sodium-dependent serotonin transporter CHEMBL228 | IC50 | 5.9 | 5.9 | 1253.2 | 1 |
| Sodium-dependent noradrenaline transporter CHEMBL222 | Ki | 5.86 | 5.86 | 1388.8 | 1 |
| Sodium-dependent noradrenaline transporter CHEMBL222 | IC50 | 5.85 | 5.85 | 1400.4 | 1 |
| Alpha-2A adrenergic receptor CHEMBL1867 | IC50 | 5.69 | 5.69 | 2023.2 | 1 |
| Sodium-dependent dopamine transporter CHEMBL238 | Ki | 5.69 | 5.69 | 2041.9 | 1 |
| Adenosine receptor A3 CHEMBL256 | Ki | 5.68 | 5.68 | 2094.6 | 1 |
| D(3) dopamine receptor CHEMBL234 | IC50 | 5.68 | 5.68 | 2103.9 | 1 |
| Substance-K receptor CHEMBL2327 | Ki | 5.64 | 5.64 | 2264.3 | 1 |
| Histamine H1 receptor CHEMBL231 | Ki | 5.61 | 5.61 | 2475.9 | 1 |
| Sodium-dependent dopamine transporter CHEMBL238 | IC50 | 5.59 | 5.59 | 2570.0 | 1 |
| Muscarinic acetylcholine receptor M5 CHEMBL2035 | Ki | 5.49 | 5.49 | 3223.5 | 1 |
| Alpha-2C adrenergic receptor CHEMBL1916 | IC50 | 5.46 | 5.46 | 3446.0 | 1 |
| Beta-3 adrenergic receptor CHEMBL246 | Ki | 5.43 | 5.43 | 3747.2 | 1 |
| Adenosine receptor A3 CHEMBL256 | IC50 | 5.43 | 5.43 | 3705.8 | 1 |
| Muscarinic acetylcholine receptor M1 CHEMBL216 | IC50 | 5.35 | 5.35 | 4505.0 | 1 |
| Muscarinic acetylcholine receptor M5 CHEMBL2035 | IC50 | 5.35 | 5.35 | 4486.8 | 1 |
| Muscarinic acetylcholine receptor M4 CHEMBL1821 | IC50 | 5.34 | 5.34 | 4561.0 | 1 |
| Muscarinic acetylcholine receptor M3 CHEMBL245 | IC50 | 5.33 | 5.33 | 4623.8 | 1 |
| Beta-3 adrenergic receptor CHEMBL246 | IC50 | 5.3 | 5.3 | 4996.3 | 1 |
| Histamine H1 receptor CHEMBL231 | IC50 | 5.29 | 5.29 | 5176.8 | 1 |
| Substance-K receptor CHEMBL2327 | IC50 | 5.17 | 5.17 | 6792.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine