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Assay Detail

CHEMBL1909162

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Binding
DRUGMATRIX: Leukotriene, BLT (LTB4) radioligand binding (ligand: [3H]LTB4)
ChEMBL ↗
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type U-937
Subcellular Membrane
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

DrugMatrix in vitro pharmacology data
Scott S. Auerbach, DrugMatrix¨ and ToxFX¨ Coordinator National Toxicology Program

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 871 5.16 6.62
Ki 871 5.75 7.21

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL55 PENTAMIDINE 4.0 2 7.21
CHEMBL404849 SULOCTIDIL 4.0 2 6.44
CHEMBL508112 BENZOTHIAZYL DISULFIDE — 2 5.89
CHEMBL1714574 TERCONAZOLE 4.0 2 5.20
CHEMBL964 DISULFIRAM 4.0 2 5.12
CHEMBL595 PIOGLITAZONE 4.0 2 4.66
CHEMBL894 BUPROPION 4.0 2 -
CHEMBL49 BUSPIRONE 4.0 2 -
CHEMBL319244 CAFFEIC ACID PHENETHYL ESTER — 2 -
CHEMBL277474 ANTIPYRINE 3.0 2 -
CHEMBL24 ATENOLOL 4.0 2 -
CHEMBL1598608 AZASETRON 2.0 2 -
CHEMBL1201346 BALSALAZIDE 4.0 2 -
CHEMBL31184 BENZO[DEF]CHRYSENE 0.5 2 -
CHEMBL415690 BETADEX 3.0 2 -
CHEMBL264374 BEZAFIBRATE 3.0 2 -
CHEMBL108 CARBAMAZEPINE 4.0 2 -
CHEMBL253376 BROMHEXINE 3.0 2 -
CHEMBL1077 BROMFENAC 4.0 2 -
CHEMBL1231530 BETAMIPRON 2.0 2 -
CHEMBL12089 BERBERINE CHLORIDE 1.0 2 -
CHEMBL221753 BENZETHONIUM CHLORIDE 2.0 2 -
CHEMBL701 BACLOFEN 4.0 2 -
CHEMBL1095699 AZASERINE 2.0 2 -
CHEMBL3084803 ASTROMICIN 2.0 2 -
CHEMBL211501 ANTIMYCIN A — 2 -
CHEMBL14 CARBACHOL 4.0 2 -
CHEMBL1458880 CADMIUM DICHLORIDE — 2 -
CHEMBL1200396 BUPIVACAINE HYDROCHLORIDE 4.0 2 -
CHEMBL844 BRIMONIDINE 4.0 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL55 PENTAMIDINE Ki = 61.0 nM 7.21
CHEMBL55 PENTAMIDINE IC50 = 242.0 nM 6.62
CHEMBL404849 SULOCTIDIL Ki = 365.5 nM 6.44
CHEMBL508112 BENZOTHIAZYL DISULFIDE Ki = 1300.0 nM 5.89
CHEMBL404849 SULOCTIDIL IC50 = 1440.5 nM 5.84
CHEMBL508112 BENZOTHIAZYL DISULFIDE IC50 = 5100.0 nM 5.29
CHEMBL1714574 TERCONAZOLE Ki = 6323.0 nM 5.20
CHEMBL964 DISULFIRAM Ki = 7583.0 nM 5.12
CHEMBL595 PIOGLITAZONE Ki = 22055.0 nM 4.66
CHEMBL1714574 TERCONAZOLE IC50 = 24919.0 nM 4.60
CHEMBL964 DISULFIRAM IC50 = 29888.0 nM 4.53
CHEMBL595 PIOGLITAZONE IC50 = 86922.0 nM 4.06
CHEMBL741 LAMOTRIGINE IC50 - — -
CHEMBL1909067 — IC50 - — -
CHEMBL741 LAMOTRIGINE Ki - — -
CHEMBL1201237 LEVOBUNOLOL IC50 - — -
CHEMBL1201237 LEVOBUNOLOL Ki - — -
CHEMBL164290 N-NITROSODIETHYLAMINE IC50 - — -
CHEMBL80 NALOXONE Ki - — -
CHEMBL80 NALOXONE IC50 - — -
CHEMBL91 MICONAZOLE Ki - — -
CHEMBL91 MICONAZOLE IC50 - — -
CHEMBL878 METOLAZONE Ki - — -
CHEMBL878 METOLAZONE IC50 - — -
CHEMBL313493 METHANESULFONIC ACID METHYL ESTER Ki - — -
CHEMBL313493 METHANESULFONIC ACID METHYL ESTER IC50 - — -
CHEMBL19215 METERGOLINE Ki - — -
CHEMBL19215 METERGOLINE IC50 - — -
CHEMBL164290 N-NITROSODIETHYLAMINE Ki - — -
CHEMBL503 LOVASTATIN Ki - — -
CHEMBL1909067 — Ki - — -
CHEMBL6437 MIANSERIN IC50 - — -
CHEMBL1630579 MYRTECAINE IC50 - — -
CHEMBL86304 MOCLOBEMIDE IC50 - — -
CHEMBL1630579 MYRTECAINE Ki - — -
CHEMBL19019 NALTREXONE IC50 - — -
CHEMBL19019 NALTREXONE Ki - — -
CHEMBL1354199 METHSCOPOLAMINE BROMIDE IC50 - — -
CHEMBL1354199 METHSCOPOLAMINE BROMIDE Ki - — -
CHEMBL86 METOCLOPRAMIDE IC50 - — -
CHEMBL86 METOCLOPRAMIDE Ki - — -
CHEMBL2106399 KITASAMYCIN Ki - — -
CHEMBL6437 MIANSERIN Ki - — -
CHEMBL1618305 NALOXONAZINE IC50 - — -
CHEMBL1618305 NALOXONAZINE Ki - — -
CHEMBL92401 IPRONIAZID IC50 - — -
CHEMBL92401 IPRONIAZID Ki - — -
CHEMBL64391 ITRACONAZOLE IC50 - — -
CHEMBL64391 ITRACONAZOLE Ki - — -
CHEMBL2106399 KITASAMYCIN IC50 - — -