Compound Detail
CHEMBL253376
BROMHEXINE 🧪 Phase III
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🧪 Phase III
Basic Information
| ChEMBL ID | CHEMBL253376 |
| Name | BROMHEXINE |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | OJGDCBLYJGHCIH-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
5
Targets
8
Activities
2
Assay Types
0
PK Parameters
20
Publications
3
Known Names
2
Indications
1
Mechanisms
Molecular Properties
376.1
MW (Da)
4.56
ALogP
2
HBA
1
HBD
29.3
PSA (Ų)
0.78
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Unknown | - | - | ✓ | ✓ |
Indications
Severe Acute Respiratory Syndrome Malaria
ATC Classification
R05CB02
bromhexine
Level 1: RESPIRATORY SYSTEM
Level 2: COUGH AND COLD PREPARATIONS
Activity Summary
IC50 5 meas. best 7.23
Ki 3 meas. best 7.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sigma non-opioid intracellular receptor 1 CHEMBL287 | Ki | 7.6 | 7.6 | 25.0 | 1 |
| Unchecked CHEMBL612545 | Ki | 7.44 | 7.44 | 36.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 7.23 | 7.23 | 59.0 | 1 |
| Sigma non-opioid intracellular receptor 1 CHEMBL287 | IC50 | 7.21 | 7.21 | 61.0 | 1 |
| Cytochrome P450 2D6 CHEMBL289 | IC50 | 6.71 | 6.71 | 195.8 | 1 |
| Sodium-dependent serotonin transporter CHEMBL228 | Ki | 5.95 | 5.95 | 1111.0 | 1 |
| Sodium-dependent serotonin transporter CHEMBL228 | IC50 | 5.68 | 5.68 | 2091.0 | 1 |
| Bile salt export pump CHEMBL6020 | IC50 | 4.69 | 4.69 | 20270.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine