Target Snapshot

CHEMBL287 Target Snapshot

Sigma non-opioid intracellular receptor 1 · SINGLE PROTEIN · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card

4,872Compounds

605Assays

146Approved Drugs

6,407.0Activities

Free Research Context

Research home keeps recent targets

This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.

Research home Demo workspace

Navigation

Switch target

Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Sigma non-opioid intracellular receptor 1 shows approved-linked disease relevance led by pain. 5 more disease programs remain visible in the same review block. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt Q99720. Start with pain, then reuse UniProt Q99720 as the stable protein anchor across project notes and exports.

Review focus

Review-ready target frame

Start with pain, then reuse UniProt Q99720 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 2 linked drugs

Open source guide

Disease program

pain

Sigma non-opioid intracellular receptor 1 shows approved-linked disease relevance led by pain. 5 more disease programs remain visible in the same review block. 2 linked drugs remain visible in the same block.

Start review with pain because it currently carries approved-linked support. Linked drugs include DEXTROMETHORPHAN HYDROBROMIDE, PENTAZOCINE HYDROCHLORIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy

Approved-linked Open Targets-ready proxy 2 linked drugs

Open disease block

Protein anchor

Sigma non-opioid intracellular receptor 1

Review this target as Sigma non-opioid intracellular receptor 1, mapped to UniProt Q99720. Sequence length is 223 aa.

Protein source · UniProt accession via ChEMBL component mapping

UniProt Q99720 Protein 223 aa

Open protein block

Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Sigma non-opioid intracellular receptor 1 as ChEMBL target CHEMBL287, mapped to UniProt Q99720. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor

Sigma non-opioid intracellular receptor 1

SINGLE PROTEIN · Homo sapiens

As of 2026-09-13

ChEMBL target ID

CHEMBL287

Primary anchor for compounds, assays, approvals, and exports

ChEMBL 36 via Core Engine As of 2026-09-13

www.ebi.ac.uk

UniProt accession

Q99720

Sigma non-opioid intracellular receptor 1

UniProt accession via ChEMBL component mapping As of 2026-09-13

www.uniprot.org

Disease evidence contract

Open Targets-ready proxy

ChEMBL drug mechanism + indication proxy

ChEMBL drug mechanism + indication proxy As of 2026-09-13

www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?

UniProt Target Context

UniProt accession via ChEMBL component mapping

Start here when your first question is whether Sigma non-opioid intracellular receptor 1 is the right protein anchor across sources, using UniProt Q99720 as the stable mapping.

Jump to Protein Context

Need disease fit before discussing compounds?

Disease Relevance & Evidence Level

ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why pain is currently framed as approved-linked support. It currently carries 2 linked drugs in the same disease frame.

Jump to Disease Context

Need a meeting-ready explanation of why this target matters?

Evidence Card

Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card

Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred Name	Sigma non-opioid intracellular receptor 1
Target Type	SINGLE PROTEIN
Organism	Homo sapiens
UniProt	Q99720

ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein Label	Sigma non-opioid intracellular receptor 1
UniProt Accession	Q99720
Component Type	Protein
Sequence Length	223 aa

Sigma non-opioid intracellular receptor 1

Source · UniProt accession via ChEMBL component mapping Freshness · Sep 13, 2026, 6:12 PM KST As of · Sep 13, 2026

UniProt Context ↗

Review Cue

How to read this target

Review this target as Sigma non-opioid intracellular receptor 1, mapped to UniProt Q99720. Sequence length is 223 aa.

Mapped IDQ99720

Review nameSigma non-opioid intracellular receptor 1

OrganismHomo sapiens

Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Sigma non-opioid intracellular receptor 1 shows approved-linked disease relevance led by pain. 5 more disease programs remain visible in the same review block.

Approved-linked Approved

pain

2 linked drugs · 2 direct · 2 efficacy