Evidence Snapshot

Sigma non-opioid intracellular receptor 1

CHEMBL287 SINGLE PROTEIN Homo sapiens

Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T09:12:57Z

Source · ChEMBL 36 via Core Engine Freshness · Sep 13, 2026, 6:12 PM KST As of · Sep 13, 2026

ChEMBL ChEMBL 36 CHEMBL287

Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Sigma non-opioid intracellular receptor 1 as ChEMBL target CHEMBL287, mapped to UniProt Q99720. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor

Sigma non-opioid intracellular receptor 1

SINGLE PROTEIN · Homo sapiens

As of 2026-09-13

ChEMBL target ID

CHEMBL287

Primary anchor for compounds, assays, approvals, and exports

ChEMBL 36 via Core Engine As of 2026-09-13

www.ebi.ac.uk

UniProt accession

Q99720

Sigma non-opioid intracellular receptor 1

UniProt accession via ChEMBL component mapping As of 2026-09-13

www.uniprot.org

Disease evidence contract

Open Targets-ready proxy

ChEMBL drug mechanism + indication proxy

ChEMBL drug mechanism + indication proxy As of 2026-09-13

www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Sigma non-opioid intracellular receptor 1 matters

As of 2026-09-13

Sigma non-opioid intracellular receptor 1 is reviewed as Sigma non-opioid intracellular receptor 1 (UniProt Q99720); Sigma non-opioid intracellular receptor 1 shows approved-linked disease relevance led by pain. 5 more disease programs remain visible in the same review block.; 2 linked drugs keep this evidence frame grounded.; the current evidence base includes 146 approved drugs, 4872 compounds, and 605 assays, with lead potency reaching pChEMBL 11.0.

Protein context

Sigma non-opioid intracellular receptor 1

Sigma non-opioid intracellular receptor 1 Sequence length is 223 aa.

Review this target as Sigma non-opioid intracellular receptor 1, mapped to UniProt Q99720. Sequence length is 223 aa.

Protein source · UniProt accession via ChEMBL component mapping

UniProt Q99720 Protein

Disease context

pain

Sigma non-opioid intracellular receptor 1 shows approved-linked disease relevance led by pain. 5 more disease programs remain visible in the same review block. 2 linked drugs keep the rationale reviewable. 5 additional disease programs remain visible in the same card. Linked drugs include DEXTROMETHORPHAN HYDROBROMIDE, PENTAZOCINE HYDROCHLORIDE.

Start review with pain because it currently carries approved-linked support. Linked drugs include DEXTROMETHORPHAN HYDROBROMIDE, PENTAZOCINE HYDROCHLORIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record

Approved-linked 2 linked drugs

Activity base

Portfolio and assay base

ChEMBL currently tracks 146 approved drugs, 4872 compounds, and 605 assays for this target. The dominant activity type is KI. CHEMBL372700 is the current potency anchor at pChEMBL 11.0.

Use CHEMBL372700 as the tractability anchor when discussing potency (pChEMBL 11.0).

Activity source · ChEMBL 36 via Core Engine

146 approved pChEMBL 11.0

Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?

Review-ready Target Rationale

One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Sigma non-opioid intracellular receptor 1 matters before drilling into raw source blocks.

Jump to Review Rationale

Need stable protein naming or accession mapping?

UniProt Target Context

UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt Q99720, not just the summarized rationale.

Open Protein Context

Need disease fit or evidence level for program framing?

Disease Relevance & Evidence Level

ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need to see why pain is currently treated as approved-linked support.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

4872

Total Compounds

605

Total Assays

146

Approved Drugs

IC50: 1885.0, KI: 4504.0, KD: 18.0

Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Compound	pChEMBL	Type	Phase
No preferred name CHEMBL372700	11.0	Ki	—
No preferred name CHEMBL5432062	10.9	Ki	—
No preferred name CHEMBL3763396	10.5	Ki	—
No preferred name CHEMBL76758	10.4	Ki	—
No preferred name CHEMBL365842	10.4	Ki	—

Approved Drugs

Structure	Compound	First Approval
	PITOLISANT HYDROCHLORIDE CHEMBL4164059	2016
	BREXPIPRAZOLE CHEMBL2105760	2015
	VILAZODONE HYDROCHLORIDE CHEMBL1615374	2011
	ILOPERIDONE CHEMBL14376	2009
	TETRACAINE CHEMBL698	2005
	CINACALCET HYDROCHLORIDE CHEMBL1200776	2004
	TEGASEROD MALEATE CHEMBL1516474	2002
	TOLTERODINE TARTRATE CHEMBL1722209	1998
	CITALOPRAM CHEMBL549	1998
	QUETIAPINE CHEMBL716	1997
	RALOXIFENE CHEMBL81	1997
	AZELASTINE HYDROCHLORIDE CHEMBL1200809	1996
	DONEPEZIL CHEMBL502	1996
	FLUVOXAMINE CHEMBL814	1994
	CISAPRIDE CHEMBL1729	1993
	TERBINAFINE CHEMBL822	1992
	SERTRALINE CHEMBL809	1991
	TICLOPIDINE CHEMBL833	1991
	REMOXIPRIDE CHEMBL22242	1990
	CLOMIPRAMINE CHEMBL415	1989
	ASTEMIZOLE CHEMBL296419	1988
	NAFTIFINE CHEMBL626	1988
	TERCONAZOLE CHEMBL1714574	1987
	FLUOXETINE CHEMBL41	1987
	BUSPIRONE CHEMBL49	1986
	LEVOBUNOLOL CHEMBL1201237	1985
	BETAXOLOL HYDROCHLORIDE CHEMBL1691	1985
	AMIODARONE CHEMBL633	1985
	LABETALOL CHEMBL429	1984
	DEXTROMETHORPHAN CHEMBL52440	1982
	TRAZODONE CHEMBL621	1981
	DEXCHLORPHENIRAMINE CHEMBL1201353	1981
	SULOCTIDIL CHEMBL404849	1979
	TIMOLOL CHEMBL499	1978
	CLEMASTINE CHEMBL1626	1977
	TAMOXIFEN CHEMBL83	1977
	LOPERAMIDE CHEMBL841	1976
	PROGESTERONE CHEMBL103	1976
	LOPERAMIDE HYDROCHLORIDE CHEMBL1707	1976
	PRAMOXINE CHEMBL1198	1976
	OXYBUTYNIN CHEMBL1231	1975
	PYRILAMINE CHEMBL511	1973
	MAZINDOL CHEMBL781	1973
	DIMENHYDRINATE CHEMBL1200406	1972
	DOXEPIN CHEMBL1628227	1969
	FENTANYL CHEMBL596	1968
	AMANTADINE CHEMBL660	1968
	PROPRANOLOL HYDROCHLORIDE CHEMBL1671	1967
	PENTAZOCINE CHEMBL100116	1967
	DIPHENIDOL CHEMBL936	1967

← Target Page

Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T09:12:57Z

Source · ChEMBL 36 via Core Engine Freshness · Sep 13, 2026, 6:12 PM KST As of · Sep 13, 2026

ChEMBL ChEMBL 36 CHEMBL287