Compound Detail
CHEMBL1671
PROPRANOLOL HYDROCHLORIDE 💊 Approved Drug
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
💊 Approved Drug
11
Targets
18
Activities
3
Assay Types
0
PK Parameters
20
Publications
30
Known Names
19
Indications
2
Mechanisms
Molecular Properties
259.4
MW (Da)
2.58
ALogP
3
HBA
2
HBD
41.5
PSA (Ų)
0.84
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1967 |
| Availability | Prescription |
| Chirality | Racemic |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Beta-1 adrenergic receptor antagonist | ANTAGONIST | Beta-1 adrenergic receptor | ✓ | ✓ |
| Beta-2 adrenergic receptor antagonist | ANTAGONIST | Beta-2 adrenergic receptor | ✓ | ✓ |
Indications
Angina Pectoris Arrhythmias, Cardiac Coronary Artery Disease Hemangioma Hypertension Migraine Disorders Stroke Wolff-Parkinson-White Syndrome Pregnancy Melanoma Movement Disorders Prostatic Neoplasms Sarcoma Sarcoma, Kaposi Urinary Bladder Neoplasms Carcinoma, Non-Small-Cell Lung Diabetes Mellitus, Type 2 Double Outlet Right Ventricle Tetralogy of Fallot
Drug Warnings
Black Box Warning
cardiotoxicity
Activity Summary
IC50 8 meas. best 8.65
Ki 7 meas. best 8.64
Kd 3 meas. best 9.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Beta-2 adrenergic receptor CHEMBL3373 | Kd | 9.05 | 9.05 | 0.9 | 1 |
| Adrenergic receptor beta CHEMBL2094118 | Kd | 8.89 | 8.89 | 1.3 | 1 |
| Beta-2 adrenergic receptor CHEMBL210 | IC50 | 8.65 | 8.65 | 2.3 | 1 |
| Beta-2 adrenergic receptor CHEMBL210 | Ki | 8.64 | 8.64 | 2.3 | 1 |
| Sigma non-opioid intracellular receptor 1 CHEMBL287 | Ki | 7.02 | 7.02 | 95.4 | 1 |
| Sigma intracellular receptor 2 CHEMBL4105907 | Ki | 6.45 | 6.45 | 352.9 | 1 |
| 5-hydroxytryptamine receptor 6 CHEMBL3371 | Ki | 6.27 | 6.27 | 542.0 | 1 |
| 5-hydroxytryptamine receptor 1A CHEMBL214 | Ki | 6.19 | 6.19 | 644.3 | 1 |
| 5-hydroxytryptamine receptor 2C CHEMBL225 | Ki | 5.86 | 5.86 | 1373.1 | 1 |
| 5-hydroxytryptamine receptor 2A CHEMBL224 | Ki | 5.75 | 5.75 | 1790.2 | 1 |
| Cavia porcellus CHEMBL369 | Kd | 5.75 | 5.75 | 1778.3 | 1 |
| Plasmodium falciparum CHEMBL364 | IC50 | 5.6 | 5.2 | 2511.9 | 7 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4689842 | HEK-293T | 9 |
| - | 10.6019/CHEMBL4689842 | Fibroblast | 9 |
| - | 10.6019/CHEMBL4689842 | U2OS | 9 |
| 9836611 | 10.1021/jm9810102 | No relevant target | 8 |
| 19734910 | 10.1038/nchembio.215 | Plasmodium falciparum | 7 |
| - | 10.6019/CHEMBL5209801 | Alpha-2A adrenergic receptor | 5 |
| - | 10.6019/CHEMBL5209801 | Adhesion G-protein coupled receptor F1 | 5 |
| - | 10.6019/CHEMBL5209801 | Glucose-dependent insulinotropic receptor | 5 |
| - | 10.6019/CHEMBL5209801 | C5a anaphylatoxin chemotactic receptor 1 | 5 |
| - | 10.6019/CHEMBL5209801 | Beta-2 adrenergic receptor | 5 |
| - | 10.6019/CHEMBL5209801 | Sphingosine 1-phosphate receptor 1 | 5 |
| - | 10.6019/CHEMBL5209801 | CX3C chemokine receptor 1 | 5 |
| - | 10.6019/CHEMBL5209801 | Free fatty acid receptor 4 | 5 |
| 6131136 | 10.1021/jm00357a027 | Rattus norvegicus | 5 |
| - | 10.6019/CHEMBL5209801 | Apelin receptor | 5 |
| - | 10.6019/CHEMBL5209801 | Type-1 angiotensin II receptor | 5 |
| - | 10.6019/CHEMBL5209801 | N-formyl peptide receptor 2 | 5 |
| - | 10.6019/CHEMBL5209801 | Glucagon-like peptide 1 receptor | 5 |
| 6115059 | 10.1021/jm00135a017 | Rattus norvegicus | 2 |
| 2993621 | 10.1021/jm00147a037 | Beta-2 adrenergic receptor | 2 |
Data from ChEMBL 36 via Core Engine