5-hydroxytryptamine receptor 1A · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-135-hydroxytryptamine receptor 1A shows approved-linked disease relevance led by major depressive disorder. 5 more disease programs remain visible in the same review block. 8 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P08908. Start with major depressive disorder, then reuse UniProt P08908 as the stable protein anchor across project notes and exports.
Start with major depressive disorder, then reuse UniProt P08908 as the stable protein anchor across project notes and exports.
5-hydroxytryptamine receptor 1A shows approved-linked disease relevance led by major depressive disorder. 5 more disease programs remain visible in the same review block. 8 linked drugs remain visible in the same block.
Start review with major depressive disorder because it currently carries approved-linked support. Linked drugs include ARIPIPRAZOLE, BREXPIPRAZOLE, GEPIRONE HYDROCHLORIDE, GSK163090. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxy5-hydroxytryptamine receptor 1A
Review this target as 5-hydroxytryptamine receptor 1A, mapped to UniProt P08908. Sequence length is 422 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats 5-hydroxytryptamine receptor 1A as ChEMBL target CHEMBL214, mapped to UniProt P08908. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether 5-hydroxytryptamine receptor 1A is the right protein anchor across sources, using UniProt P08908 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why major depressive disorder is currently framed as approved-linked support. It currently carries 8 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | 5-hydroxytryptamine receptor 1A |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P08908 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 5-hydroxytryptamine receptor 1A |
| UniProt Accession | P08908 |
| Component Type | Protein |
| Sequence Length | 422 aa |
5-hydroxytryptamine receptor 1A
Review this target as 5-hydroxytryptamine receptor 1A, mapped to UniProt P08908. Sequence length is 422 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
5-hydroxytryptamine receptor 1A shows approved-linked disease relevance led by major depressive disorder. 5 more disease programs remain visible in the same review block.
Start review with major depressive disorder because it currently carries approved-linked support. Linked drugs include ARIPIPRAZOLE, BREXPIPRAZOLE, GEPIRONE HYDROCHLORIDE, GSK163090. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL199824 | 11.0 | EC50 | 0.01 | Preclinical |
| CHEMBL4790600 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL4790600 | 10.99 | EC50 | 0.01023 | Preclinical |
| CHEMBL4746386 | 10.89 | Ki | 0.01288 | Preclinical |
| CHEMBL4757755 | 10.88 | EC50 | 0.01318 | Preclinical |
| CHEMBL4755058 | 10.86 | EC50 | 0.0138 | Preclinical |
| CHEMBL1258761 | 10.85 | Ki | 0.0141 | Preclinical |
| CHEMBL4742112 | 10.83 | Ki | 0.01479 | Preclinical |
| CHEMBL1258533 | 10.82 | Ki | 0.0152 | Preclinical |
| CHEMBL4760271 | 10.8 | Ki | 0.01585 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 671 | 1,668 | 7.2 |
| cell-based format | 417 | 2,989 | 7.5 |
| tissue-based format | 43 | 163 | 7.5 |
| assay format | 37 | 593 | 8.2 |
| cell membrane format | 24 | 147 | 7.1 |
| organism-based format | 2 | 35 | 8.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 309 | 586 | 7.6 |
| assay format | 130 | 286 | 7.5 |
| single protein format | 11 | 87 | 7.5 |
| cell membrane format | 6 | 7 | 7.5 |
| organism-based format | 2 | 0 | — |
| tissue-based format | 2 | 10 | 6.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 4 | 3 | 5.7 |
| single protein format | 3 | 0 | — |
| cell membrane format | 2 | 6 | 6.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 0 | — |