Compound Detail
CHEMBL578767
FLUMEXADOL 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL578767 |
| Name | FLUMEXADOL |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | GXPYCYWPUGKQIJ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
1
Known Names
Molecular Properties
231.2
MW (Da)
2.37
ALogP
2
HBA
1
HBD
21.3
PSA (Ų)
0.80
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Withdrawn |
| Chirality | Racemic |
Drug Warnings
Withdrawn
General Warning
benefit/risk ratio for these products is negative
Activity Summary
Kd 1 meas. best 6.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A CHEMBL214 | Kd | 6.6 | 6.6 | 251.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Kd | = | 251.19 | nM | 6.6 | Binding affinity to 5HT1A receptor | 19754201 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| 19754201 | 10.1021/jm901096y | 5-hydroxytryptamine receptor 1A | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
Data from ChEMBL 36 via Core Engine